Journal article
Topical Effect of Intravesical Oxybutynin
The Journal of urology, Vol.150(5 Part 1), pp.1522-1525
11/1993
DOI: 10.1016/S0022-5347(17)35834-2
PMID: 8411446
Abstract
Intravesical oxybutynin was instilled into rat bladders in graded doses by repeated catheterization to study the local bladder effects of drug concentration and incidental urinary infection. On the thirteenth day, after 5 doses, bladders were recovered for measurement and histological study. In the highest dose group, systemic absorption from the bladder caused weight loss and cachexia. However, in no group was there any clear evidence of drug-related mucosal or bladder wall change. Instead, the two high dose groups seemed somehow protected from the combined adverse effects of catheterization and infection.
Details
- Title: Subtitle
- Topical Effect of Intravesical Oxybutynin
- Creators
- William W Bonney - From the Departments of Urology and Pathology, University of Iowa, Iowa City, Iowa, The Department of Pharmacology, Kirksville College of Osteopathic Medicine, Kirksville, MissouriRobert A Robinson - From the Departments of Urology and Pathology, University of Iowa, Iowa City, Iowa, The Department of Pharmacology, Kirksville College of Osteopathic Medicine, Kirksville, MissouriRobert J Theobald - From the Departments of Urology and Pathology, University of Iowa, Iowa City, Iowa, The Department of Pharmacology, Kirksville College of Osteopathic Medicine, Kirksville, Missouri
- Resource Type
- Journal article
- Publication Details
- The Journal of urology, Vol.150(5 Part 1), pp.1522-1525
- DOI
- 10.1016/S0022-5347(17)35834-2
- PMID
- 8411446
- ISSN
- 0022-5347
- eISSN
- 1527-3792
- Language
- English
- Date published
- 11/1993
- Academic Unit
- Oral Pathology, Radiology and Medicine; Pathology; Urology
- Record Identifier
- 9984047642902771
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