Journal article
Topical Ocular Delivery of Nanocarriers: A Feasible Choice for Glaucoma Management
Current pharmaceutical design, Vol.26(42), pp.5518-5532
09/16/2020
DOI: 10.2174/1381612826666200916145609
PMID: 32938345
Abstract
: Topical ocular delivery is an acceptable and familiar approach for the treatment of common ocular diseases. Novel strategies for the treatment of inherited eye diseases include new pharmacologic agents, gene therapy and genome editing, which lead to expansion of new management options for eye disorders. Topical ocular delivery of nanocarriers is a technique, which has the potential to facilitate novel treatments. Nanocarrier-based strategies have proven effective for site-targeted delivery. This review summarizes recent development in the area of topical delivery of different nanocarriers (Polymer, Vesicular and dispersed systems) for the management of glaucoma, a group of ocular disorders characterized by progressive and accelerated degeneration of the axons of retinal ganglion cells, which make up the optic nerve. Unique cellular targets for glaucoma treatment, primarily the trabecular meshwork of the anterior segment of the eye, make glaucoma facilitated by the use of nanocarriers an ideal disorder for novel molecular therapies.
Details
- Title: Subtitle
- Topical Ocular Delivery of Nanocarriers: A Feasible Choice for Glaucoma Management
- Creators
- Karthikeyan Kesavan - Department of Pharmaceutics, SLT Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur, C.G, IndiaParasuraman Mohan - Department of Pharmaceutics, SLT Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur, C.G, IndiaNivedita Gautam - Department of Pharmaceutics, SLT Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur, C.G, IndiaVal C Sheffield - Department of Pediatrics, Division of Medical Genetics and Genomics, Carver College of Medicine, University of Iowa, IA, United States
- Resource Type
- Journal article
- Publication Details
- Current pharmaceutical design, Vol.26(42), pp.5518-5532
- DOI
- 10.2174/1381612826666200916145609
- PMID
- 32938345
- ISSN
- 1381-6128
- eISSN
- 1873-4286
- Language
- English
- Date published
- 09/16/2020
- Academic Unit
- Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Medical Genetics and Genomics; Ophthalmology and Visual Sciences
- Record Identifier
- 9984070224602771
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