Journal article
Topiramate depresses carbachol-induced plateau potentials in subicular bursting cells
Neuroreport, Vol.11(1), pp.75-77
01/17/2000
DOI: 10.1097/00001756-200001170-00015
PMID: 10683833
Abstract
Intracellular recordings were made in an in vitro slice preparation to establish whether the antiepileptic drug topiramate reduces the depolarizing plateau potentials (PPs) induced in the rat subiculum by intracellular pulses of depolarizing current, in the presence of the cholinergic agonist carbachol (CCh, 70–100 μM). PPs lasted up to about 2 s, and disappeared during application of the muscarinic receptor antagonist atropine. Topiramate (10–100 μM, n = 22 neurons) decreased and eventually abolished in a dose-dependent manner these PPs, even when the function of excitatory amino acid and GABAA receptors was blocked. Hence, topiramate depresses muscarinic receptor-dependent PPs in the rat subiculum, thus suggesting that this form of excitation may represent a target for the mechanism of action of this antiepileptic compound.
Details
- Title: Subtitle
- Topiramate depresses carbachol-induced plateau potentials in subicular bursting cells
- Creators
- Carmela Palmieri - 1Montreal Neurological Institute and Departments of Neurology and Neurosurgery and Physiology, McGill University, 3801 University St, Montréal, Québec, H3A 2B4 Canada 2Centro per lʼEpilessia, Ospedale San Paolo, Università degli Studi di Milano, 20142 Milano, ItalyHiroto KawasakiMassimo Avoli
- Resource Type
- Journal article
- Publication Details
- Neuroreport, Vol.11(1), pp.75-77
- Publisher
- Lippincott Williams & Wilkins, Inc
- DOI
- 10.1097/00001756-200001170-00015
- PMID
- 10683833
- ISSN
- 0959-4965
- eISSN
- 1473-558X
- Language
- English
- Date published
- 01/17/2000
- Academic Unit
- Neurosurgery
- Record Identifier
- 9984083819102771
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