Topographical Analysis of Aneurysm Wall Enhancement With 3‐Dimensional Mapping

Ashrita Raghuram; Alberto Varon; Sebastian Sanchez; Daizo Ishii; Chaorong Wu; Vincent A. Magnotta; David M. Hasan; Timothy R. Koscik; Edgar A. Samaniego

doi:10.1161/SVIN.121.000309

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Topographical Analysis of Aneurysm Wall Enhancement With 3‐Dimensional Mapping

Journal article

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Topographical Analysis of Aneurysm Wall Enhancement With 3‐Dimensional Mapping

Ashrita Raghuram, Alberto Varon, Sebastian Sanchez, Daizo Ishii, Chaorong Wu, Vincent A. Magnotta, David M. Hasan, Timothy R. Koscik and Edgar A. Samaniego

Stroke: Vascular and Interventional Neurology, Vol.2(4), e000309

05/08/2022

DOI: 10.1161/SVIN.121.000309

PMCID: PMC9432773

PMID: 36061513

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https://doi.org/10.1161/SVIN.121.000309View

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Abstract

BACKGROUND Aneurysm wall enhancement has been identified as a potential biomarker for aneurysm instability. Enhancement has been determined by different approaches on 2‐dimensional multiplanar views. This study describes a new method to quantify enhancement through 3‐dimensional (3D) heatmaps and histograms. METHODS A custom algorithm was developed using orthogonal probes extending from the aneurysm lumen into the wall to create 3D heatmaps and histograms of wall enhancement on 7T magnetic resonance imaging. Three quantitative metrics for general, specific, and focal wall enhancement were generated from the histograms. RESULTS Thirty‐two aneurysms were analyzed and classified based on 3D heatmaps and histograms. Larger aneurysms were more enhancing (Spearman r =0.472; P =0.006) and had more heterogeneous enhancement (Spearman r =0.557; P <0.001) than smaller aneurysms. Patterns of enhancement differed between saccular, fusiform, and thrombosed aneurysms. Fusiform aneurysms were larger ( P =0.015) and had more heterogenous enhancement compared with saccular aneurysms. Fusiform aneurysms had more areas of focal enhancement ( P <0.001) and right‐skewed histograms ( P =0.003). CONCLUSION The 3D analysis of aneurysm wall enhancement provides topographic data of the entire aneurysm wall. New metrics developed based on this method show that large and fusiform aneurysms have heterogenous enhancement.

Details

Title: Subtitle: Topographical Analysis of Aneurysm Wall Enhancement With 3‐Dimensional Mapping
Creators: Ashrita Raghuram - University of Iowa
Alberto Varon - Roy J. and Lucille A. Carver College of Medicine
Sebastian Sanchez - University of Iowa
Daizo Ishii - University of Iowa
Chaorong Wu - University of Iowa
Vincent A. Magnotta - University of Iowa
David M. Hasan - Duke University
Timothy R. Koscik - University of Iowa
Edgar A. Samaniego - Roy J. and Lucille A. Carver College of Medicine
Resource Type: Journal article
Publication Details: Stroke: Vascular and Interventional Neurology, Vol.2(4), e000309
DOI: 10.1161/SVIN.121.000309
PMID: 36061513
PMCID: PMC9432773
NLM abbreviation: Stroke Vasc Interv Neurol
ISSN: 2694-5746
eISSN: 2694-5746
Language: English
Date published: 05/08/2022
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Neurology; Radiology; Psychiatry; Iowa Neuroscience Institute; Neurosurgery
Record Identifier: 9984274860002771

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