Journal article
Torsades de pointes associated with chlorpromazine : Case report and review of associated ventricular arrhythmias
Pharmacotherapy, Vol.21(7), pp.871-883
2001
DOI: 10.1592/phco.21.9.871.34565
PMID: 11444585
Abstract
Purpose: To present a case of chlorpromazine-associated torsades de pointes, review established cases of ventricular arrhythmias associated with chlorpromazine, and describe the proarrhythmic characteristics of this drug.
Data sources: Articles identified through a search of MEDLINE and IDIS from January 1966-November 2000 and thorough review of the article bibliographies. Patient cases also were identified from a search of the Food and Drug Administration's Adverse Event Reporting System database (November 1997-March 2001). Cases involving intentional overdoses of chlorpromazine were excluded.
Results: In addition to the case reported herein, 12 cases of documented, chlorpromazine-associated ventricular arrhythmias were identified; five had characteristic features of torsades de pointes. Chlorpromazine delayed repolarization and produced electrocardiographic abnormalities; although, whether chlorpromazine induced torsades de pointes through a mechanism of early afterdepolarizations is unclear. Similar to other instances of drug-induced torsades de pointes, concurrent factors such as electrolyte deficiencies may place the patient at increased risk for arrhythmia.
Conclusions: Chlorpromazine can delay repolarization and produce electrocardiographic abnormalities. These can result infrequently in ventricular arrhythmias and torsades de pointes, particularly in patients with confounding factors.
Details
- Title: Subtitle
- Torsades de pointes associated with chlorpromazine : Case report and review of associated ventricular arrhythmias
- Creators
- James D HOEHNS - Colleges of Pharmacy and Medicine, University of Iowa, and the Veterans Affairs Medical Center, Iowa City, Iowa, United StatesRichard H STANFORD - Colleges of Pharmacy and Medicine, University of Iowa, and the Veterans Affairs Medical Center, Iowa City, Iowa, United StatesDouglas R GERAETS - Colleges of Pharmacy and Medicine, University of Iowa, and the Veterans Affairs Medical Center, Iowa City, Iowa, United StatesKelly S SKELLY - Colleges of Pharmacy and Medicine, University of Iowa, and the Veterans Affairs Medical Center, Iowa City, Iowa, United StatesHon-Chi LEE - Colleges of Pharmacy and Medicine, University of Iowa, and the Veterans Affairs Medical Center, Iowa City, Iowa, United StatesBrian L GAUL - Colleges of Pharmacy and Medicine, University of Iowa, and the Veterans Affairs Medical Center, Iowa City, Iowa, United States
- Resource Type
- Journal article
- Publication Details
- Pharmacotherapy, Vol.21(7), pp.871-883
- Publisher
- Pharmacotherapy; Boston, MA
- DOI
- 10.1592/phco.21.9.871.34565
- PMID
- 11444585
- ISSN
- 0277-0008
- eISSN
- 1875-9114
- Language
- English
- Date published
- 2001
- Academic Unit
- Family and Community Medicine; Pharmacy Practice and Science
- Record Identifier
- 9984025292102771
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