Journal article
Total Synthesis of (±)-Cytisine
Organic letters, Vol.2(26), pp.4201-4204
12/01/2000
DOI: 10.1021/ol0067538
PMID: 11150199
Abstract
[reaction:see text] The nicotine partial agonist cytisine was prepared in five steps featuring an "in situ" Stille or Suzuki biaryl pyridine coupling. Differentiation of the pyridyl rings was accomplished via selective benzylation and then reduction of a pyridinium ring. The penultimate diazabicyclo[3.3.1]nonane intermediate was obtained with high diastereoselectivity. A similar sequence has been employed for the synthesis of novel derivative 9-methoxycytisine.
Details
- Title: Subtitle
- Total Synthesis of (±)-Cytisine
- Creators
- Brian T O'Neill - Pfizer Global Research and Development, Pfizer Inc., 8220-4111 Groton, Connecticut 06340Daniel Yohannes - Pfizer Global Research and Development, Pfizer Inc., 8220-4111 Groton, Connecticut 06340Mark W Bundesmann - Pfizer Global Research and Development, Pfizer Inc., 8220-4111 Groton, Connecticut 06340Eric P Arnold - Pfizer Global Research and Development, Pfizer Inc., 8220-4111 Groton, Connecticut 06340
- Resource Type
- Journal article
- Publication Details
- Organic letters, Vol.2(26), pp.4201-4204
- DOI
- 10.1021/ol0067538
- PMID
- 11150199
- ISSN
- 1523-7060
- eISSN
- 1523-7052
- Language
- English
- Date published
- 12/01/2000
- Academic Unit
- Endocrinology and Metabolism; Internal Medicine
- Record Identifier
- 9984094764702771
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