Journal article
Total and regional cerebral blood flow measurement with 7-10-, 15-, 25-, and 50-mum microspheres
Journal of applied physiology (1948), Vol.40(4), pp.501-507
04/1976
DOI: 10.1152/jappl.1976.40.4.501
PMID: 931870
Abstract
Cerebral arteriovenous shunting of 7-10-, 15-, 25-, and 50-mum labeled microspheres was studied in 12 anesthetized dogs. Approximately 8% of the 7-10-mum spheres were shunted to cerebral venous blood, whereas less than 2% of the 15-, 25-, and 50-mum spheres were shunted. Cerebral vascular dilatation induced by hypoxia or hypercapnia did not alter the shunting. The calculated total cerebral flow was 10-15% lower with 7-10-mum microspheres as compared with simultaneous flows measured with the larger microspheres which also suggests that 7-10-mu spheres were shunted through the brain. The calculated distribution of cerebral flow was similar with 7-10- and 15-mum spheres but markedly altered when 50-mum spheres were used. Repeated injections of 15-mum spheres were used. Repeated injections of 15-mum microspheres given under stable conditions yielded total cerebral blood flows which averaged +/- 6% of their respective mean and the regional distribution of flow was highly reproducible. These data suggest that, in dogs, 15-mum spheres are an appropriate size to use to measure cerebral blood flows, since shunting is minimal, the distribution is not artifactually distorted, and the measurements are reproducible.
Details
- Title: Subtitle
- Total and regional cerebral blood flow measurement with 7-10-, 15-, 25-, and 50-mum microspheres
- Creators
- M L MarcusD D HeistadJ C EhrhardtF M Abboud
- Resource Type
- Journal article
- Publication Details
- Journal of applied physiology (1948), Vol.40(4), pp.501-507
- Publisher
- United States
- DOI
- 10.1152/jappl.1976.40.4.501
- PMID
- 931870
- ISSN
- 0021-8987
- eISSN
- 2691-2473
- Language
- English
- Date published
- 04/1976
- Academic Unit
- Radiology; Molecular Physiology and Biophysics; Cardiovascular Medicine; Fraternal Order of Eagles Diabetes Research Center; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984025463802771
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