Total and regional gray matter volume is not related to APOEE4 status in a community sample of middle-aged individuals

Nicolas Cherbuin; Kaarin J. Anstey; Perminder S. Sachdev; Jerome J. Maller; Chantal Meslin; Holly A. Mack; Wei Wen; Simon Easteal

doi:10.1093/gerona/63.5.501

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Total and regional gray matter volume is not related to APOEE4 status in a community sample of middle-aged individuals

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Total and regional gray matter volume is not related to APOEE4 status in a community sample of middle-aged individuals

Nicolas Cherbuin, Kaarin J. Anstey, Perminder S. Sachdev, Jerome J. Maller, Chantal Meslin, Holly A. Mack, Wei Wen and Simon Easteal

The journals of gerontology. Series A, Biological sciences and medical sciences, Vol.63(5), pp.501-504

05/01/2008

DOI: 10.1093/gerona/63.5.501

PMID: 18511754

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Abstract

Background. The APOE*E4 allele has been associated with greater gray matter atrophy and with Alzheimer's disease. The aim of this study was to investigate whether the relationship between cerebral gray matter atrophy and APOE*E4 genotype was also present in a community-dwelling, nondemented 60- to 64-year-old cohort. Methods. Hippocampal and amygdalar volumes were manually traced and analyzed on 331 cranial T1-weighted magnetic resonance imaging (MRI) scans to detect differences associated with APOE*E4 genotype. Voxel-based morphometric (VBM) analyses were applied to detect regional gray matter volume differences. Results. No total, hippocampal, or amygdalar gray matter volume difference was detected between APOE*E4 carriers and noncarriers. Conclusions. In nondemented 60- to 64-year-olds, there was no association between APOE genotype and gray matter volume using both region-of-interest analysis and VBM.

Geriatrics & Gerontology

Gerontology

Life Sciences & Biomedicine

Science & Technology

Details

Title: Subtitle: Total and regional gray matter volume is not related to APOEE4 status in a community sample of middle-aged individuals
Creators: Nicolas Cherbuin - Australian National University
Kaarin J. Anstey - Australian National University
Perminder S. Sachdev - UNSW Sydney
Jerome J. Maller - Monash Health
Chantal Meslin - UNSW Sydney
Holly A. Mack - Australian National University
Wei Wen - UNSW Sydney
Simon Easteal - Australian National University
Resource Type: Journal article
Publication Details: The journals of gerontology. Series A, Biological sciences and medical sciences, Vol.63(5), pp.501-504
DOI: 10.1093/gerona/63.5.501
PMID: 18511754
NLM abbreviation: J Gerontol A Biol Sci Med Sci
ISSN: 1079-5006
eISSN: 1758-535X
Publisher: Gerontological Soc Amer
Number of pages: 4
Language: English
Date published: 05/01/2008
Academic Unit: Radiology
Record Identifier: 9984848508602771

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