Journal article
Total and specific fluid consumption as determinants of bladder cancer risk
International journal of cancer, Vol.118(8), pp.2040-7
04/15/2006
DOI: 10.1002/ijc.21587
PMID: 16284957
Abstract
We pooled the data from 6 case-control studies of bladder cancer with detailed information on fluid intake and water pollutants, particularly trihalomethanes (THM), and evaluated the bladder cancer risk associated with total and specific fluid consumption. The analysis included 2,729 cases and 5,150 controls. Odds ratios (OR) and 95% confidence intervals (CI) for fluid consumption were adjusted for age, gender, study, smoking status, occupation and education. Total fluid intake was associated with an increased risk of bladder cancer in men. The adjusted OR for 1 l/day increase in intake was 1.08, (95% CI 1.03-1.14, p-value for linear trend <0.001), while no trend was observed in women (OR=1.04, 0.94-1.15; p-value=0.7). OR was 1.33 (1.12-1.58) for men in the highest category of intake (>3.5 l/day) as compared to those in the lowest (2 l/day vs. 5 cups of coffee daily vs. <5 and for THM exposure, but neither exposure confounded or modified the OR for tap water intake. The association of bladder cancer with tap water consumption, but not with nontap water fluids, suggests that carcinogenic chemicals in tap water may explain the increased risk.
Details
- Title: Subtitle
- Total and specific fluid consumption as determinants of bladder cancer risk
- Creators
- Cristina M VillanuevaKenneth P CantorWill D KingJouni J. K JaakkolaSylvaine Cordier - Groupe d'Etude de la Reproduction Chez l'Homme et les MammiferesCharles F LynchStefano PorruManolis Kogevinas
- Resource Type
- Journal article
- Publication Details
- International journal of cancer, Vol.118(8), pp.2040-7
- Publisher
- Wiley
- DOI
- 10.1002/ijc.21587
- PMID
- 16284957
- ISSN
- 0020-7136
- eISSN
- 1097-0215
- Grant note
- name: European Commission DG SANCO Project, award: 2001/CAN/112; name: DURSI grant, Government of Catalonia, award: 2001/SGR/00406; name: FIS, award: 01/1326E; name: EPICUR-red, award: ISIII-GO3/174
- Language
- English
- Date published
- 04/15/2006
- Academic Unit
- Epidemiology
- Record Identifier
- 9983995107802771
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