Journal article
Total energy expenditure as assessed by doubly-labeled water and all-cause mortality in a cohort of postmenopausal women
The American journal of clinical nutrition, Vol.117(5), pp.955-963
05/2023
DOI: 10.1016/j.ajcnut.2023.02.023
PMCID: PMC10273089
PMID: 36889672
Abstract
The association of total energy expenditure with all-cause mortality is uncertain, as is the dependence of this association on age.
To examine the association between total energy expenditure and all-cause mortality, and its age interaction, in a Women’s Health Initiative (WHI) cohort of postmenopausal U.S. females (1992-present).
A cohort of 1,131 WHI participants having Doubly-Labeled Water (DLW) total energy expenditure (TEE) assessment about 10.0 years (median) following WHI enrollment with about 13.7 years (median) of subsequent follow-up, was used to study energy expenditure associations with all-cause mortality. To enhance the comparability of TEE and total energy intake, key analyses excluded participants having more than 5% weight change between WHI enrollment and DLW assessment. The influence of participant age on mortality associations was examined, as was the ability of concurrent and earlier weight and height measures to explain results.
There were 308 deaths following TEE assessment through 2021. TEE was unrelated to mortality (P=0.83) overall in this cohort of generally healthy, older (mean 71 years at TEE assessment) U.S. females. However, this potential association varied with age (P=0.003). Higher TEE was associated with higher mortality rate at age 60 and lower mortality rate at age 80. Within the weight stable subset (532 participants, 129 deaths), TEE was weakly positively related to mortality overall (P=0.08). This association also varied with age (P=0.03), with mortality HRs (95% CIs) for a 20% increment in TEE of 2.33 (1.24, 4.36) at age 60, 1.49 (1.10, 2.02) at age 70, and 0.96 (0.66, 1.38) at age 80. This pattern remained, though was somewhat attenuated, following control for baseline weight and weight changes between WHI enrollment and TEE assessment.
Higher energy expenditure is associated with higher all-cause mortality among younger postmenopausal females, only partially explained by weight and weight change.
This study is registered with clinicaltrials.gov identifier: NCT00000611.
Details
- Title: Subtitle
- Total energy expenditure as assessed by doubly-labeled water and all-cause mortality in a cohort of postmenopausal women
- Creators
- Ross L. Prentice - Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WAAaron K. Aragaki - Fred Hutch Cancer CenterJoAnn E. Manson - Brigham and Women's HospitalDale A. Schoeller - University of Wisconsin–MadisonLesley F. Tinker - Fred Hutch Cancer CenterYasmin Mossavar-Rahmani - Albert Einstein College of MedicineRobert B. Wallace - University of IowaMichael J. LaMonte - University at Buffalo, State University of New YorkJanet A. Tooze - Wake Forest UniversityKaren C. Johnson - University of Tennessee at KnoxvilleJohanna W. Lampe - Fred Hutch Cancer CenterMarian L. Neuhouser - Fred Hutch Cancer Center
- Resource Type
- Journal article
- Publication Details
- The American journal of clinical nutrition, Vol.117(5), pp.955-963
- DOI
- 10.1016/j.ajcnut.2023.02.023
- PMID
- 36889672
- PMCID
- PMC10273089
- NLM abbreviation
- Am J Clin Nutr
- ISSN
- 0002-9165
- eISSN
- 1938-3207
- Publisher
- Elsevier Inc
- Grant note
- DOI: 10.13039/100000002, name: National Institutes of Health; DOI: 10.13039/100000016, name: U.S. Department of Health and Human Services, award: HHSN268202100001C, HHSN268202100002C, HHSN268202100003C, HHSN268202100004C, HHSN268202100046C, HHSN271202100004C; DOI: 10.13039/100000050, name: National Heart, Lung, and Blood Institute; DOI: 10.13039/100000054, name: National Cancer Institute, award: R01 CA119171
- Language
- English
- Electronic publication date
- 03/06/2023
- Date published
- 05/2023
- Academic Unit
- Epidemiology; Injury Prevention Research Center
- Record Identifier
- 9984375357602771
Metrics
8 Record Views