Total lymphocyte count: not a surrogate marker for risk of death in HIV-infected Ugandan children

Philippa M Musoke; Alicia M Young; Maxensia A Owor; Irene R Lubega; Elizabeth R Brown; Francis A Mmiro; Lynne M Mofenson; J Brooks Jackson; Mary Glenn Fowler; Laura A Guay

doi:10.1097/QAI.0b013e318183a92a

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Total lymphocyte count: not a surrogate marker for risk of death in HIV-infected Ugandan children

Journal article

Open access

Peer reviewed

Total lymphocyte count: not a surrogate marker for risk of death in HIV-infected Ugandan children

Philippa M Musoke, Alicia M Young, Maxensia A Owor, Irene R Lubega, Elizabeth R Brown, Francis A Mmiro, Lynne M Mofenson, J Brooks Jackson, Mary Glenn Fowler and Laura A Guay

Journal of acquired immune deficiency syndromes (1999), Vol.49(2), pp.171-178

10/01/2008

DOI: 10.1097/QAI.0b013e318183a92a

PMCID: PMC2721476

PMID: 18769352

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Abstract

To determine the utility of total lymphocyte count (TLC) in predicting the 12-month mortality in HIV-infected Ugandan children and to correlate TLC and CD4 cell %. This is a retrospective data analysis of clinical and laboratory data collected prospectively on 128 HIV-infected children in the HIV Network for Prevention Trials 012 trial. TLC and CD4 cell % measurements were obtained at birth, 14 weeks, and 12, 24, 36, 48, and 60 months of age and assessed with respect to risk of death within 12 months. Median TLC per microliter (CD4 cell %) was 4150 (41%) at birth, 4900 (24%) at 12 months, 4300 (19%) at 24 months, 4150 (19%) at 36 months, 4100 (18%) at 48 months, and 3800 (20%) at 60 months. The highest risk of mortality within 12 months was 34% - 37% at birth and declined to 13%-15% at 24 months regardless of TLC measurement. The correlation between CD4 cell % and TLC was extremely low overall (r = 0.01). The TLC did not predict a risk of progression to death within 12 months in HIV-infected Ugandan children. Therefore, TLC alone may not be a useful surrogate marker for determining those children at highest risk of death, who require antiretroviral therapy most urgently.

Prognosis

Humans

Child, Preschool

Infant

CD4 Lymphocyte Count

HIV Infections - immunology

HIV Infections - diagnosis

Biomarkers

Lymphocyte Count

HIV Infections - mortality

Uganda

Retrospective Studies

Longitudinal Studies

Infant, Newborn

Details

Title: Subtitle: Total lymphocyte count: not a surrogate marker for risk of death in HIV-infected Ugandan children
Creators: Philippa M Musoke - Department of Paediatrics and Child Health, Makerere University, Kampala, Uganda. pmusoke@mujhu.org
Alicia M Young
Maxensia A Owor
Irene R Lubega
Elizabeth R Brown
Francis A Mmiro
Lynne M Mofenson
J Brooks Jackson
Mary Glenn Fowler
Laura A Guay
Resource Type: Journal article
Publication Details: Journal of acquired immune deficiency syndromes (1999), Vol.49(2), pp.171-178
DOI: 10.1097/QAI.0b013e318183a92a
PMID: 18769352
PMCID: PMC2721476
NLM abbreviation: J Acquir Immune Defic Syndr
ISSN: 1525-4135
eISSN: 1944-7884
Publisher: United States
Grant note: U01 AI 48054 / NIAID NIH HHS U01 AI048054 / NIAID NIH HHS U01 AI 069530 / NIAID NIH HHS U01 AI068632 / NIAID NIH HHS U01 AI 068632 / NIAID NIH HHS N01 AI035173 / NIAID NIH HHS U01 AI068613 / NIAID NIH HHS N01 AI045200 / NIAID NIH HHS N01 AI 35173 / NIAID NIH HHS N01 AI 45200 / NIAID NIH HHS U01 AI048054-01 / NIAID NIH HHS U01 AI 46745 / NIAID NIH HHS U01 AI069530 / NIAID NIH HHS U01 AI 068613 / NIAID NIH HHS U01 AI046745 / NIAID NIH HHS
Language: English
Date published: 10/01/2008
Academic Unit: Pathology; VPMA - Administration
Record Identifier: 9984047790302771

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