Journal article
Total pancreatectomy and islet autotransplantation in chronic pancreatitis: recommendations from PancreasFest
Pancreatology : official journal of the International Association of Pancreatology (IAP), Vol.14(1), pp.27-35
01/2014
DOI: 10.1016/j.pan.2013.10.009
PMCID: PMC4058640
PMID: 24555976
Abstract
Total pancreatectomy with islet autotransplantation (TPIAT) is a surgical procedure used to treat severe complications of chronic pancreatitis or very high risk of pancreatic cancer while reducing the risk of severe diabetes mellitus. However, clear guidance on indications, contraindications, evaluation, timing, and follow-up are lacking.
A working group reviewed the medical, psychological, and surgical options and supporting literature related to TPIAT for a consensus meeting during PancreasFest.
Five major areas requiring clinical evaluation and management were addressed: These included: 1) indications for TPIAT; 2) contraindications for TPIAT; 3) optimal timing of the procedure; 4) need for a multi-disciplinary team and the roles of the members; 5) life-long management issues following TPIAP including diabetes monitoring and nutrition evaluation.
TPIAT is an effective method of managing the disabling complications of chronic pancreatitis and risk of pancreatic cancer in very high risk patients. Careful evaluation and long-term management of candidate patients by qualified multidisciplinary teams is required. Multiple recommendations for further research were also identified.
Details
- Title: Subtitle
- Total pancreatectomy and islet autotransplantation in chronic pancreatitis: recommendations from PancreasFest
- Creators
- Melena D Bellin - Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA. Electronic address: bell0130@umn.eduMartin L Freeman - Department of Medicine, University of Minnesota, Minneapolis, MN, USAAndres Gelrud - Department of Medicine, University of Chicago, Chicago, IL, USAAdam Slivka - Department of Medicine, University of Pittsburgh, PA, USAAlfred Clavel - Department of Neurology, University of Minnesota, Minneapolis, MN, USAAbhinav Humar - Department of Surgery, University of Pittsburgh, PA, USASarah J Schwarzenberg - Department of Pediatrics, University of Minnesota, Minneapolis, MN, USAMark E Lowe - Department of Pediatrics, University of Pittsburgh, PA, USA; Children's Hospital of Pittsburgh, PA, USAMichael R Rickels - Department of Medicine, University of Pennsylvania, Philadelphia, PA, USADavid C Whitcomb - Department of Medicine, University of Pittsburgh, PA, USA. Electronic address: whitcomb@pitt.eduJeffrey B Matthews - Department of Surgery, University of Chicago, Chicago, IL, USAStephen AmannDana K AndersenMichelle A AndersonJohn BaillieGeoffrey BlockRandall BrandSuresh ChariMarie CookGregory A CoteTy DunnLuca FrulloniJulia B GreerMichael A HollingsworthKyung Mo KimAlexander LarsonMarkus M LerchTom LinThiruvengadam MunirajR Paul RobertsonSeth SclairShalinender SinghRachelle StopczynskiFrederico G S ToledoCharles Melbern WilcoxJohn WindsorDhiraj YadavPancreasFest Recommendation Conference Participants
- Contributors
- Aliye Uc (Contributor) - University of Iowa, Stead Family Department of Pediatrics
- Resource Type
- Journal article
- Publication Details
- Pancreatology : official journal of the International Association of Pancreatology (IAP), Vol.14(1), pp.27-35
- DOI
- 10.1016/j.pan.2013.10.009
- PMID
- 24555976
- PMCID
- PMC4058640
- NLM abbreviation
- Pancreatology
- ISSN
- 1424-3903
- eISSN
- 1424-3911
- Publisher
- Switzerland
- Grant note
- R13 DK083216 / NIDDK NIH HHS R01 CA177857 / NCI NIH HHS R13DK083216 / NIDDK NIH HHS R01 DK039994 / NIDDK NIH HHS R13DK088452 / NIDDK NIH HHS R13 DK088452 / NIDDK NIH HHS K23 DK084315 / NIDDK NIH HHS R13 DK096904 / NIDDK NIH HHS R13DK09604 / NIDDK NIH HHS F32 DK009604 / NIDDK NIH HHS R13 DK100242 / NIDDK NIH HHS K12 HD052892 / NICHD NIH HHS
- Language
- English
- Date published
- 01/2014
- Academic Unit
- Stead Family Department of Pediatrics; Radiation Oncology; Gastroenterology, Hepatology, Pancreatology, and Nutrition
- Record Identifier
- 9984047666802771
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