Journal article
Total synthesis of ( R, R, R)- and ( S, S, S)-schweinfurthin F: Differences of bioactivity in the enantiomeric series
Bioorganic & medicinal chemistry letters, Vol.17(4), pp.911-915
2007
DOI: 10.1016/j.bmcl.2006.11.096
PMID: 17236766
Abstract
Total synthesis of the ( R, R, R)- and ( S, S, S)-enantiomers of the natural product schweinfurthin F has been completed. Comparisons of spectral data and optical rotations with those reported for the natural product, as well as a variety of bioassay data, allow assignment of the natural material as the ( R, R, R)-isomer.
Details
- Title: Subtitle
- Total synthesis of ( R, R, R)- and ( S, S, S)-schweinfurthin F: Differences of bioactivity in the enantiomeric series
- Creators
- Nolan R Mente - Department of Chemistry, University of Iowa, Iowa City, IA 52242-1294, USAAndrew J Wiemer - Program in Molecular and Cellular Biology, University of Iowa, Iowa City, IA 52242-1294, USAJeffrey D Neighbors - Department of Chemistry, University of Iowa, Iowa City, IA 52242-1294, USAJohn A Beutler - Molecular Targets Development Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702-1201, USARaymond J Hohl - Program in Molecular and Cellular Biology, University of Iowa, Iowa City, IA 52242-1294, USADavid F Wiemer - Department of Chemistry, University of Iowa, Iowa City, IA 52242-1294, USA
- Resource Type
- Journal article
- Publication Details
- Bioorganic & medicinal chemistry letters, Vol.17(4), pp.911-915
- Publisher
- Elsevier Ltd
- DOI
- 10.1016/j.bmcl.2006.11.096
- PMID
- 17236766
- ISSN
- 0960-894X
- eISSN
- 1464-3405
- Language
- English
- Date published
- 2007
- Academic Unit
- Neuroscience and Pharmacology; Chemistry; Internal Medicine
- Record Identifier
- 9983985828802771
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