Journal article
Toward a positive aging phenotype for older women: observations from the women's health initiative
The journals of gerontology. Series A, Biological sciences and medical sciences, Vol.67(11), pp.1191-1196
11/2012
DOI: 10.1093/gerona/gls117
PMCID: PMC3667695
PMID: 22518819
Abstract
To develop a positive aging phenotype, we undertook analyses to describe multiple dimensions of positive aging and their relationships to one another in women 65 years of age and older and evaluate the performance of individual indicators and composite factors of this phenotype as predictors of time to death, years of healthy living, and years of independent living.
Data from Women's Health Initiative clinical trial and observational study participants ages 65 years and older at baseline, including follow-up observations up to 8 years later, were analyzed using descriptive statistics and principal components analysis to identify the factor structure of a positive aging phenotype. The factors were used to predict time to death, years of healthy living (without hospitalization or diagnosis of a serious health condition), and years of independent living (without nursing home admission or use of special services).
We identified a multidimensional phenotype of positive aging that included two factors: Physical-Social Functioning and Emotional Functioning. Both factors were predictive of each of the outcomes, but Physical-Social Functioning was the strongest predictor. Each standard deviation of increase in Physical-Social Functioning was accompanied by a 23.7% reduction in mortality risk, a 19.4% reduction in risk of major health conditions or hospitalizations, and a 26.3% reduction in risk of dependent living.
Physical-Social Functioning and Emotional Functioning constitute important components of a positive aging phenotype. Physical-Social Functioning was the strongest predictor of outcomes related to positive aging, including years of healthy living, years of independent living, and time to mortality.
Details
- Title: Subtitle
- Toward a positive aging phenotype for older women: observations from the women's health initiative
- Creators
- Nancy Fugate Woods - Biobehavioral Nursing and Health Systems, University of Washington, Seattle, WA, USA. nfwoods@uw.eduBarbara B CochraneAndrea Z LaCroixRebecca A SeguinOleg ZaslavskyJingmin LiuJeannette M BeasleyRobert L BrunnerMark A EspelandJoseph S GoveasDorothy S LaneJoAnn E MansonCharles P MoutonJennifer G RobinsonLesley F Tinker
- Resource Type
- Journal article
- Publication Details
- The journals of gerontology. Series A, Biological sciences and medical sciences, Vol.67(11), pp.1191-1196
- Publisher
- United States
- DOI
- 10.1093/gerona/gls117
- PMID
- 22518819
- PMCID
- PMC3667695
- ISSN
- 1079-5006
- eISSN
- 1758-535X
- Grant note
- N01WH42123 / WHI NIH HHS N01WH32111 / WHI NIH HHS N01WH42132 / WHI NIH HHS N01WH42118 / WHI NIH HHS N01WH42114 / WHI NIH HHS N01WH42110 / WHI NIH HHS N01WH32106 / WHI NIH HHS N01WH32119 / WHI NIH HHS N01WH32115 / WHI NIH HHS N01WH32102 / WHI NIH HHS N01WH24152 / WHI NIH HHS N01WH32101 / WHI NIH HHS N01WH42131 / WHI NIH HHS N01WH42108 / WHI NIH HHS N01WH42126 / WHI NIH HHS N01WH42113 / WHI NIH HHS N01WH42117 / WHI NIH HHS N01WH44221 / WHI NIH HHS N01WH32109 / WHI NIH HHS N01WH32105 / WHI NIH HHS N01WH32118 / WHI NIH HHS N01WH42122 / WHI NIH HHS N01WH42107 / WHI NIH HHS N01WH42130 / WHI NIH HHS N01WH42125 / WHI NIH HHS N01WH42112 / WHI NIH HHS K01 HL108807 / NHLBI NIH HHS N01WH42129 / WHI NIH HHS N01WH32122 / WHI NIH HHS N01WH42116 / WHI NIH HHS N01WH32108 / WHI NIH HHS N01WH32113 / WHI NIH HHS N01WH32100 / WHI NIH HHS N01WH42121 / WHI NIH HHS N01WH42115 / WHI NIH HHS N01WH42124 / WHI NIH HHS N01WH32112 / WHI NIH HHS N01WH42119 / WHI NIH HHS N01WH22110 / WHI NIH HHS N01WH42111 / WHI NIH HHS N01WH42120 / WHI NIH HHS N01WH42109 / WHI NIH HHS
- Language
- English
- Date published
- 11/2012
- Academic Unit
- Epidemiology; Internal Medicine
- Record Identifier
- 9983996195902771
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