Journal article
Toward an Understanding of the Molecules that Sense Myocardial Ischemia
Annals of the New York Academy of Sciences, Vol.940(1), pp.96-109
06/2001
DOI: 10.1111/j.1749-6632.2001.tb03669.x
PMID: 11458710
Abstract
: Cardiac afferent neurons are activated in the setting of myocardial ischemia and mediate the sensation of angina. However, the precise stimuli and receptive molecules responsible are not completely understood. To further investigate the molecular components involved, cardiac afferents were isolated in dissociated culture and patch‐clamp experiments were performed on these cells. It was found that acidic pH evoked large inward currents in almost all cardiac sympathetic afferents. By comparison, the responses to other potential chemical mediators were inconsistent and much smaller. The biophysical properties of the acid‐evoked currents in cardiac afferents match the acid‐sensing ion channel 3 (ASIC3).
Details
- Title: Subtitle
- Toward an Understanding of the Molecules that Sense Myocardial Ischemia
- Creators
- CHRISTOPHER J BENSONSTEPHANI P SUTHERLAND
- Resource Type
- Journal article
- Publication Details
- Annals of the New York Academy of Sciences, Vol.940(1), pp.96-109
- DOI
- 10.1111/j.1749-6632.2001.tb03669.x
- PMID
- 11458710
- NLM abbreviation
- Ann N Y Acad Sci
- ISSN
- 0077-8923
- eISSN
- 1749-6632
- Publisher
- Blackwell Publishing Ltd; Oxford, UK
- Number of pages
- 14
- Language
- English
- Date published
- 06/2001
- Academic Unit
- Cardiovascular Medicine; Fraternal Order of Eagles Diabetes Research Center; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984040494802771
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