Journal article
Toward improved anti-cryptococcal drugs: Novel molecules and repurposed drugs
Fungal genetics and biology, Vol.78, pp.93-98
05/2015
DOI: 10.1016/j.fgb.2014.12.001
PMID: 25514636
Abstract
•Review of the current state of anti-cryptococcal therapy.•Proposal for ideal anti-cryptococcal therapy.•Review of recent progress toward new therapies.
Cryptococcosis is one of the most important fungal infections of humans. It primarily, but not exclusively, afflicts people with compromised immune function. Cryptococcosis is most commonly caused by Cryptococcus neoformans var. grubii with C. neoformans var. neoformans and C. gatti also contributing to the disease. Cryptococcosis is primarily manifested as meningoencephalitis although pneumonia occurs frequently as well. Globally, the burden of disease is highest among those living with HIV/AIDS and is one of the most common causes of death in this patient population. Cryptococcal meningitisis almost invariably fatal if untreated. The current gold standard therapy is amphotericin B combined with 5-flucytosine. Unfortunately, this therapy has significant toxicity and is not widely available in resource-limited regions. Fluconazole, which is associated with poorer outcomes, is frequently as an alternative. Here, I present the characteristics of an ideal anti-cryptococcal agent and review recent progress toward identifying both novel and repurposed drugs as potential new therapies.
Details
- Title: Subtitle
- Toward improved anti-cryptococcal drugs: Novel molecules and repurposed drugs
- Creators
- Damian J Krysan - Department of Microbiology/Immunology, University of Rochester, School of Medicine and Dentistry, Rochester, NY 14642, United States
- Resource Type
- Journal article
- Publication Details
- Fungal genetics and biology, Vol.78, pp.93-98
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.fgb.2014.12.001
- PMID
- 25514636
- ISSN
- 1087-1845
- eISSN
- 1096-0937
- Grant note
- DOI: 10.13039/100000002, name: NIH, award: 1R01AI091422 and 1R01AI097142
- Language
- English
- Date published
- 05/2015
- Academic Unit
- Microbiology and Immunology; Stead Family Department of Pediatrics; Infectious Disease (Pediatrics)
- Record Identifier
- 9984093348202771
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