Towards the development of a supercritical carbon dioxide spray process to coat solid protein particles

Miao Yu; Ahmad S. Sediq; Shiduo Zhang; M. Reza Nejadnik; Hayley A. Every; Wim Jiskoot; Geert-Jan Witkamp

doi:10.1016/j.supflu.2017.12.014

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Towards the development of a supercritical carbon dioxide spray process to coat solid protein particles

Journal article

Peer reviewed

Towards the development of a supercritical carbon dioxide spray process to coat solid protein particles

Miao Yu, Ahmad S. Sediq, Shiduo Zhang, M. Reza Nejadnik, Hayley A. Every, Wim Jiskoot and Geert-Jan Witkamp

The Journal of supercritical fluids, Vol.141, pp.49-59

11/2018

DOI: 10.1016/j.supflu.2017.12.014

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Abstract

[Display omitted] •A supercritical carbon dioxide spray process was developed to coat solid protein particles.•A hydrophilic, biocompatible polyelectrolyte was used as the coating material.•This process can be used as the stepping stone for the coating of solid protein particles with polymeric multi-layer shell. The aim of this study was to develop a supercritical carbon dioxide (scCO2) spray process to coat solid protein particles with a hydrophilic polymer. The final purpose is to manufacture drug particles exhibiting controlled release behaviour in patients. Lysozyme microparticles (about 20 μm) were suspended in a vessel into which a dextran sulphate (DS) solution was dispersed by scCO2 via a nozzle. Upon interaction with the droplets, DS was deposited onto or mixed with suspended lysozyme particles. Particles of about 100 μm were obtained. The zeta-potential analysis and elemental analysis indicated that the top layer of the particles consisted of both lysozyme and DS. Some of the produced particulate materials showed retarded lysozyme release when exposed to water or phosphate buffered saline, holding promise for future production of controlled drug delivery systems for therapeutic proteins.

Dextran sulphate

Drug delivery systems

Lysozyme

Proteins

Supercritical carbon dioxide

Details

Title: Subtitle: Towards the development of a supercritical carbon dioxide spray process to coat solid protein particles
Creators: Miao Yu - Delft University of Technology
Ahmad S. Sediq - Centre for Human Drug Research
Shiduo Zhang - Delft University of Technology
M. Reza Nejadnik - Centre for Human Drug Research
Hayley A. Every - FeyeCon (Netherlands)
Wim Jiskoot - Leiden University
Geert-Jan Witkamp - Delft University of Technology
Resource Type: Journal article
Publication Details: The Journal of supercritical fluids, Vol.141, pp.49-59
DOI: 10.1016/j.supflu.2017.12.014
ISSN: 0896-8446
eISSN: 1872-8162
Publisher: Elsevier B.V
Grant note: name: the Netherlands Organisation for Scientific Research (NWO) Domain Applied and Engineering Sciences (TTW), award: 12144; DOI: 10.13039/501100004725, name: Ministry of Economic Affairs
Language: English
Date published: 11/2018
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Pharmaceutical Sciences and Experimental Therapeutics
Record Identifier: 9984420940602771

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