Journal article
Toxic Effects of Cu Implants on Liver
Toxicological sciences, Vol.4(5), pp.778-783
1984
DOI: 10.1093/toxsci/4.5.778
PMID: 6510609
Abstract
In an effort to identify possible systemic effects due to dissolution of Cu from the experimental use of dental amalgam, specimens of pure Cu and several dental amalgams containing various concentrations of Cu were implanted into the peritoneal cavity of rats for 4 weeks. Concentrations of Cu in the liver varied from 33.3 to 156.2 micrograms Cu/dry g of liver tissue after implantation of the Cu-containing amalgams. Histopathological changes in the liver confirmed the presence of Cu within the lysosomes of hepatocytes. The histopathological and chemical changes in the liver after implantation indicated the need for subsequent investigations of long-term systemic toxicity to the use of Cu-containing implants.
Details
- Title: Subtitle
- Toxic Effects of Cu Implants on Liver
- Creators
- JOHN C KELLEREDWARD J KAMINSKI
- Resource Type
- Journal article
- Publication Details
- Toxicological sciences, Vol.4(5), pp.778-783
- DOI
- 10.1093/toxsci/4.5.778
- PMID
- 6510609
- ISSN
- 1096-6080
- eISSN
- 1096-0929
- Language
- English
- Date published
- 1984
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Graduate College Admin and Gen; President; Oral and Maxillofacial Surgery; Dental Research
- Record Identifier
- 9984065999602771
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