Journal article
Toxic shock syndrome-associated staphylococcal and streptococcal pyrogenic toxins are potent inducers of tumor necrosis factor production
Infection and immunity, Vol.57(1), pp.291-294
01/1989
DOI: 10.1128/IAI.57.1.291-294.1989
PMCID: PMC313091
PMID: 2642470
Abstract
Toxic shock syndrome-associated staphylococcal and streptococcal exotoxins were tested for an ability to induce the production of tumor necrosis factor (TNF). Staphylococcal enterotoxins B and C1, along with streptococcal pyrogenic exotoxin A, all induced TNF production in a dose-dependent manner, with production peaking on the average at 3 days but continuing over the 6 days tested. This time course of exotoxin-induced TNF production contrasts with the 1-day peak-2-day duration observed with endotoxin as the stimulus and may be significant to development of toxic shock syndrome.
Details
- Title: Subtitle
- Toxic shock syndrome-associated staphylococcal and streptococcal pyrogenic toxins are potent inducers of tumor necrosis factor production
- Creators
- D J Fast - Department of Microbiology, University of Minnesota, Minneapolis 55455P M Schlievert - Department of Microbiology, University of Minnesota, Minneapolis 55455R D Nelson - Department of Microbiology, University of Minnesota, Minneapolis 55455
- Resource Type
- Journal article
- Publication Details
- Infection and immunity, Vol.57(1), pp.291-294
- DOI
- 10.1128/IAI.57.1.291-294.1989
- PMID
- 2642470
- PMCID
- PMC313091
- ISSN
- 0019-9567
- eISSN
- 1098-5522
- Language
- English
- Date published
- 01/1989
- Academic Unit
- Microbiology and Immunology; Internal Medicine
- Record Identifier
- 9984001156602771
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