Journal article
Toxicity of busulfan and cyclophosphamide (BU/CY2) in patients with hematologic malignancies
Bone marrow transplantation (Basingstoke), Vol.17(3), pp.329-333
1996
PMID: 8704682
Abstract
Between July 1991 and January 1994, 52 patients with hematologic malignancies underwent BMT using BU/CY2 as conditioning regimen. Median patient age was 38 years. Eleven patients underwent autologous BMT, 22 HLA-identical allogeneic BMT, and 19 patients underwent a MUD or an allogeneic mismatched BMT. GVHD prophylaxis was with cyclosporine/methylprednisone in 26 patients; T cell depletion was used in 15 patients. VOD was observed in 7.5% of patients, IP in 12%, seizures in 4%. The overall incidence of grade II-IV acute GVHD was 35%. Delayed platelet engraftment was observed in seven of 11 patients who underwent autologous BMT. Graft failure was seen in seven of 19 (37%) patients who underwent MUD or allogeneic mismatched BMT. Six of the seven patients received T cell depletion as GVHD prophylaxis. BU/CY2 transplantation from an unrelated or family-mismatched donor with T cell depletion is associated with a high incidence of graft failure.
Details
- Title: Subtitle
- Toxicity of busulfan and cyclophosphamide (BU/CY2) in patients with hematologic malignancies
- Creators
- M DEMAGALHAES-SILVERMAN - Division of Hematology/Bone Marrow Transplantation, Pittsburgh Cancer Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, United StatesE. J BLOOM - Division of Hematology/Bone Marrow Transplantation, Pittsburgh Cancer Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, United StatesA DONNENBERG - Division of Hematology/Bone Marrow Transplantation, Pittsburgh Cancer Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, United StatesJ LISTER - Division of Hematology/Bone Marrow Transplantation, Pittsburgh Cancer Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, United StatesS PINCUS - Division of Hematology/Bone Marrow Transplantation, Pittsburgh Cancer Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, United StatesW. B RYBKA - Division of Hematology/Bone Marrow Transplantation, Pittsburgh Cancer Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, United StatesE. D BALL - Division of Hematology/Bone Marrow Transplantation, Pittsburgh Cancer Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, United States
- Resource Type
- Journal article
- Publication Details
- Bone marrow transplantation (Basingstoke), Vol.17(3), pp.329-333
- Publisher
- Nature Publishing Group
- PMID
- 8704682
- ISSN
- 0268-3369
- eISSN
- 1476-5365
- Language
- English
- Date published
- 1996
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
- Record Identifier
- 9984094752402771
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