Journal article
Toxicity of hydroxylated polychlorinated biphenyls (HO-PCBs) using the bioluminescent assay Microtox (R)
Ecotoxicology (London), Vol.25(7), pp.1438-1444
09/01/2016
DOI: 10.1007/s10646-016-1693-z
PMCID: PMC5131519
PMID: 27411941
Abstract
Hydroxylated polychlorinated biphenyls (HO-PCBs) are toxic contaminants which are produced in the environment by biological or abiotic oxidation of PCBs. The toxicity of a suite of 23 mono-hydroxylated derivatives of PCBs and 12 parent PCBs was determined using the bacterial bioluminescent assay Microtox(A (R)). All HO-PCBs tested exhibited higher toxicity than the corresponding parent PCB, with effect concentration 50 % (EC50) ranging from 0.07 to 133 mg L-1. The highest toxicities were recorded with 4-hydroxylated derivatives of di-chlorinated biphenyls (EC50 = 0.07-0.36 mg L-1) and 2-hydroxylated derivatives of tri-chlorinated biphenyls carrying a chlorine substituent on the phenolic ring (EC50 = 0.34-0.48 mg L-1). The toxicity of HO-PCBs generally decreased when the degree of chlorination increased. Consistently with this observation, a significant positive correlation was measured between toxicity (measured by EC50) and octanol-water partition coefficient (pK (ow)) for the HO-PCBs under study (Pearson's correlation coefficient, r = 0.74), which may be explained by the lower solubility and bioavailability generally associated with higher hydrophobicity. This study is the first one which assessed the toxicity of a suite of PCBs and HO-PCBs using the bioluminescent assay Microtox(A (R)), showing an inverse correlation between toxicity and hydrophobicity.
Details
- Title: Subtitle
- Toxicity of hydroxylated polychlorinated biphenyls (HO-PCBs) using the bioluminescent assay Microtox (R)
- Creators
- Renu Bhalla - Temple Univ, Dept Civil & Environm Engn, 1947 N 12th St, Philadelphia, PA 19122 USARouzbeh Tehrani - Temple UniversityBenoit Van Aken - Temple University
- Resource Type
- Journal article
- Publication Details
- Ecotoxicology (London), Vol.25(7), pp.1438-1444
- Publisher
- Springer Nature
- DOI
- 10.1007/s10646-016-1693-z
- PMID
- 27411941
- PMCID
- PMC5131519
- ISSN
- 0963-9292
- eISSN
- 1573-3017
- Number of pages
- 7
- Grant note
- P42ES013661 / NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) P42 ES013661 / Iowa Superfund Basic Research Program, National Institute of Environmental Health Sciences
- Language
- English
- Date published
- 09/01/2016
- Academic Unit
- Iowa Superfund Research Program
- Record Identifier
- 9984297955802771
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