Toxicokinetics of chiral polychlorinated biphenyls across different species--a review

Izabela Kania-Korwel; Hans-Joachim Lehmler

doi:10.1007/s11356-015-4383-0

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Toxicokinetics of chiral polychlorinated biphenyls across different species--a review

Journal article

Open access

Peer reviewed

Toxicokinetics of chiral polychlorinated biphenyls across different species--a review

Izabela Kania-Korwel and Hans-Joachim Lehmler

Environmental science and pollution research international, Vol.23(3), pp.2058-2080

02/2016

DOI: 10.1007/s11356-015-4383-0

PMCID: PMC4591098

PMID: 25824003

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http://doi.org/10.1007/s11356-015-4383-0View

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Abstract

Nineteen polychlorinated biphenyls (chiral or C-PCBs) exist as two stable rotational isomers (atropisomers) that are non-superimposable mirror images of each other. C-PCBs are released into the environment as racemic (i.e., equal) mixtures of both atropisomers and undergo atropisomeric enrichment due to biological, but not abiotic, processes. In particular, toxicokinetic studies provide important initial insights into atropselective processes involved in the disposition (i.e., absorption, distribution, biotransformation, and excretion) of C-PCBs. The toxicokinetic of C-PCBs is highly congener and species dependent. In particular, at lower trophic levels, abiotic processes play a predominant role in C-PCB toxicokinetics. Biotransformation plays an important role in the elimination of C-PCBs in mammals. The elimination of C-PCB follows the approximate order mammals > birds > amphibians > fish, mostly due to a corresponding decrease in metabolic capacity. A few studies have shown differences in the toxicokinetics of C-PCB atropisomers; however, more work is needed to understand the toxicokinetics of C-PCBs and the underlying biological processes. Such studies will not only contribute to our understanding of the fate of C-PCBs in aquatic and terrestrial food webs but also facilitate our understanding of human exposures to C-PCBs.

Toxicokinetics

Food Chain

Animals

Polychlorinated Biphenyls - chemistry

Polychlorinated Biphenyls - toxicity

Species Specificity

Stereoisomerism

Biotransformation

Humans

Polychlorinated Biphenyls - pharmacokinetics

Synthesis Core

Details

Title: Subtitle: Toxicokinetics of chiral polychlorinated biphenyls across different species--a review
Creators: Izabela Kania-Korwel - Department of Occupational and Environmental Health, College of Public Health, The University of Iowa, UI Research Park, #221 IREH, Iowa City, IA, USA
Hans-Joachim Lehmler - Department of Occupational and Environmental Health, College of Public Health, The University of Iowa, UI Research Park, #221 IREH, Iowa City, IA, USA. hans-joachim-lehmler@uiowa.edu
Resource Type: Journal article
Publication Details: Environmental science and pollution research international, Vol.23(3), pp.2058-2080
DOI: 10.1007/s11356-015-4383-0
PMID: 25824003
PMCID: PMC4591098
NLM abbreviation: Environ Sci Pollut Res Int
ISSN: 0944-1344
eISSN: 1614-7499
Publisher: Germany
Grant note: P30 ES005605 / NIEHS NIH HHS R01 ES017425 / NIEHS NIH HHS P42 ES013661 / NIEHS NIH HHS ES012475 / NIEHS NIH HHS ES017425 / NIEHS NIH HHS ES05605 / NIEHS NIH HHS K25 ES012475 / NIEHS NIH HHS ES013661 / NIEHS NIH HHS
Language: English
Date published: 02/2016
Academic Unit: Occupational and Environmental Health; Iowa Neuroscience Institute; Iowa Superfund Research Program
Record Identifier: 9984000927802771

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