Toxocara canis infection of the eye. Correlation of clinical observations with developing pathology in the primate model

R C Watzke; J A Oaks; J C Folk

doi:10.1001/archopht.1984.01040030226032

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Toxocara canis infection of the eye. Correlation of clinical observations with developing pathology in the primate model

Journal article

Peer reviewed

Toxocara canis infection of the eye. Correlation of clinical observations with developing pathology in the primate model

R C Watzke, J A Oaks and J C Folk

Archives of ophthalmology (1960), Vol.102(2), pp.282-291

02/1984

DOI: 10.1001/archopht.1984.01040030226032

PMID: 6696677

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Abstract

A primate model for the study of Toxocara canis infection was created by intravitreal, periocular, systemic, and intracarotid injection of viable larvae in cynomolgus monkeys. The results were as follows: (1) Intravitreal larvae caused retinal hemorrhages, perivasculitis, mild vitritis, and retinal nodules. (2) Apparently viable larvae without inflammatory reaction were found in the vitreous, retina, and optic nerves up to nine months after intravitreal inoculation. (3) Other larvae were surrounded by an acute inflammatory granuloma or a chronic fibrotic granuloma, but they did not appear to be necrotic. (4) Toxocara canis larvae apparently had the ability to move through ocular tissue, to leave the site of tissue reaction, and to exit via the optic nerve. Viable larvae were found in the retina up to 15 months after inoculation. (5) Culture fluid containing Toxocara proteins stimulated a severe retinal vasculitis. Dead larvae caused little reaction. (6) Positive aqueous and vitreous enzyme-linked immunosorbent assay titers were found in the most severely inflamed eyes, which often harbored live larvae.

Ascariasis - pathology

Eye - pathology

Enzyme-Linked Immunosorbent Assay

Eye - parasitology

Eye Diseases - immunology

Toxocariasis - pathology

Macaca fascicularis

Animals

Eye - immunology

Time Factors

Toxocariasis - immunology

Larva - pathogenicity

Eye Diseases - parasitology

Eye Diseases - pathology

Toxocariasis - parasitology

Toxocara - pathogenicity

Disease Models, Animal

Details

Title: Subtitle: Toxocara canis infection of the eye. Correlation of clinical observations with developing pathology in the primate model
Creators: R C Watzke
J A Oaks
J C Folk
Resource Type: Journal article
Publication Details: Archives of ophthalmology (1960), Vol.102(2), pp.282-291
DOI: 10.1001/archopht.1984.01040030226032
PMID: 6696677
NLM abbreviation: Arch Ophthalmol
ISSN: 0003-9950
eISSN: 1538-3601
Publisher: American Medical Association; United States
Language: English
Date published: 02/1984
Academic Unit: Ophthalmology and Visual Sciences
Record Identifier: 9983980396002771

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