Toxoplasma Encephalitis following Tandem Autologous Hematopoietic Stem Cell Transplantation: A Case Report and Review of the Literature

Vidya Kollu; Margarida Magalhaes-Silverman; Guido Tricot; Dilek Ince

doi:10.1155/2018/9409121

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Toxoplasma Encephalitis following Tandem Autologous Hematopoietic Stem Cell Transplantation: A Case Report and Review of the Literature

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Toxoplasma Encephalitis following Tandem Autologous Hematopoietic Stem Cell Transplantation: A Case Report and Review of the Literature

Vidya Kollu, Margarida Magalhaes-Silverman, Guido Tricot and Dilek Ince

Case reports in infectious diseases, Vol.2018, pp.1-3

01/01/2018

DOI: 10.1155/2018/9409121

PMCID: PMC6252224

PMID: 30534451

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Abstract

Infection with Toxoplasma gondii is a rare but often fatal complication in hematopoietic stem cell transplantation (HSCT) recipients. Most cases have been reported in allogeneic (allo-) HSCT recipients, with only narrative reports following autologous HSCT (ASCT). We report the case of a 58-year-old Caucasian male presenting with toxoplasma encephalitis following tandem ASCT for myeloma and successfully treated with diagnosis by polymerase chain reaction analysis of cerebrospinal fluid. He was treated with sulfadiazine and pyrimethamine (with leucovorin) followed by pyrimethamine and atovaquone as secondary prophylaxis while receiving subsequent therapy for progressive multiple myeloma. Toxoplasmosis is a potential complication in allo-HSCT as well as ASCT recipients and should be considered in any post-HSCT patient with neurological dysfunction. Rapid diagnosis and immediate antimicrobial treatment are essential to avoid morbidity and mortality.

Infectious Diseases

Life Sciences & Biomedicine

Science & Technology

Details

Title: Subtitle: Toxoplasma Encephalitis following Tandem Autologous Hematopoietic Stem Cell Transplantation: A Case Report and Review of the Literature
Creators: Vidya Kollu - University of Iowa
Margarida Magalhaes-Silverman - University of Iowa
Guido Tricot - University of Iowa
Dilek Ince - University of Iowa
Resource Type: Journal article
Publication Details: Case reports in infectious diseases, Vol.2018, pp.1-3
DOI: 10.1155/2018/9409121
PMID: 30534451
PMCID: PMC6252224
NLM abbreviation: Case Rep Infect Dis
ISSN: 2090-6625
eISSN: 2090-6633
Publisher: Hindawi Publishing Group
Number of pages: 3
Language: English
Date published: 01/01/2018
Academic Unit: Infectious Diseases; Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
Record Identifier: 9984362301502771

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