Journal article
Toxoplasmosis Titers and Past Suicide Attempts Among Older Adolescents Initiating SSRI Treatment
Archives of suicide research, Vol.20(4), pp.605-613
2016
DOI: 10.1080/13811118.2016.1158677
PMCID: PMC5067776
PMID: 27045220
Abstract
Latent infection with toxoplasmosis is a prevalent condition that has been linked in animal studies to high-risk behaviors, and in humans, to suicide and suicide attempts. This analysis investigated a relationship between suicide attempt history and toxoplasmosis titers in a group of older adolescents who had recently begun treatment with an SSRI. Of 108 participants, 17 (15.7 %) had a lifetime history of at least one suicide attempt. All were given structured and unstructured diagnostic interviews and provided blood samples. Two individuals (11.9%) with a past suicide attempt, and two (2.1%) without this history, had toxoplasmosis titers ≥ 10 IU/ml (p = 0.166). Those with a past suicide attempt had mean toxoplasmosis titers that were significantly different (p = 0.018) from those of patients who lacked this history. An ROC analysis suggested a lower optimal threshold for distinguishing patients with and without suicide attempts (3.6 IU/ml) than that customarily used to identify seropositivity. Toxoplasmosis titers may quantify a proneness to suicidal behavior in younger individuals being treated with antidepressants.
Details
- Title: Subtitle
- Toxoplasmosis Titers and Past Suicide Attempts Among Older Adolescents Initiating SSRI Treatment
- Creators
- William Coryell - Department of Psychiatry, University of Iowa, Iowa City, Iowa, USARobert Yolken - Stanley Division of Developmental Neurovirology, Johns Hopkins University, Baltimore, Maryland, USABrandon Butcher - Department of Psychiatry, University of Iowa, Iowa City, Iowa, USATrudy Burns - Department of Epidemiology, University of Iowa, Iowa City, Iowa, USALilian Dindo - Department of Psychiatry, Baylor College of Medicine, Houston, Texas, USAJanet Schlechte - Department of Endocrinology, University of Iowa, Iowa City, Iowa, USAChadi Calarge - Department of Psychiatry and Behaviorial Sciences, Baylor College of Medicine, Houston, Texas, USA
- Resource Type
- Journal article
- Publication Details
- Archives of suicide research, Vol.20(4), pp.605-613
- DOI
- 10.1080/13811118.2016.1158677
- PMID
- 27045220
- PMCID
- PMC5067776
- NLM abbreviation
- Arch Suicide Res
- ISSN
- 1381-1118
- eISSN
- 1543-6136
- Grant note
- DOI: 10.13039/100000097, name: National Center for Research Resources, award: 2ULTR000442-6; DOI: 10.13039/100000025, name: National Institute of Mental Health, award: R01MH090072
- Language
- English
- Date published
- 2016
- Academic Unit
- Psychiatry; Epidemiology; Internal Medicine
- Record Identifier
- 9984004076802771
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