Trace Element Concentrations of Arsenic and Selenium in Toenails and Risk of Prostate Cancer among Pesticide Applicators

Leslie K Dennis; Marvin E Langston; Laura Beane Freeman; Robert A Canales; Charles F Lynch

doi:10.3390/curroncol31090405

Back

Trace Element Concentrations of Arsenic and Selenium in Toenails and Risk of Prostate Cancer among Pesticide Applicators

Journal article

Open access

Peer reviewed

Trace Element Concentrations of Arsenic and Selenium in Toenails and Risk of Prostate Cancer among Pesticide Applicators

Leslie K Dennis, Marvin E Langston, Laura Beane Freeman, Robert A Canales and Charles F Lynch

Current oncology (Toronto), Vol.31(9), pp.5472-5483

09/14/2024

DOI: 10.3390/curroncol31090405

PMCID: PMC11430890

PMID: 39330033

Files and links (1)

url

https://doi.org/10.3390/curroncol31090405View

Published (Version of record) Open Access

Abstract

Prostate cancer is a common cancer among males in the US, but little is known about its risk factors, including trace elements. The primary aim of this study was to examine prostate cancer and its association with arsenic and selenium in toenails. We conducted a small, nested case-control study of men residing in Iowa within the Agricultural Health Study cohort, where we also collected toenail samples to test for arsenic and other trace elements. Toenail samples were sent for neutron activation analysis aimed at long-lived trace elements, including arsenic. Logistic regression was used to estimate odds ratios (ORs) for trace element exposures and prostate cancer. A total of 66 prostate cancer cases and 173 healthy controls returned questionnaires, over 99% of which included toenail samples. An increased risk was seen for the highest levels of arsenic (OR = 3.4 confidence interval (CI) of 1.3-8.6 and OR = 2.2, 95% CI of 0.9-5.6) and the highest level of selenium (2.0, 95% CI of 1.0-4.0). These data also show detectable levels of over 50% for 14 of 22 elements detected in the toenails. The association seen here with arsenic and prostate cancer further supports ecological studies finding an association with community levels of arsenic and prostate cancer incidence and mortality.

Aged

Arsenic - analysis

Case-Control Studies

Humans

Male

Middle Aged

Nails - chemistry

Occupational Exposure - adverse effects

Occupational Exposure - analysis

Pesticides - analysis

Prostatic Neoplasms - epidemiology

Risk Factors

Selenium - analysis

Trace Elements - analysis

Details

Title: Subtitle: Trace Element Concentrations of Arsenic and Selenium in Toenails and Risk of Prostate Cancer among Pesticide Applicators
Creators: Leslie K Dennis - University of Iowa
Marvin E Langston - University of Arizona
Laura Beane Freeman - Division of Cancer Epidemiology and Genetics
Robert A Canales - University of Arizona
Charles F Lynch - University of Iowa
Resource Type: Journal article
Publication Details: Current oncology (Toronto), Vol.31(9), pp.5472-5483
DOI: 10.3390/curroncol31090405
PMID: 39330033
PMCID: PMC11430890
NLM abbreviation: Curr Oncol
ISSN: 1718-7729
eISSN: 1718-7729
Publisher: MDPI
Grant note: Z01-CP010119 / NCI NIH HHS R03-CA099524 / NCI NIH HHS N01-PC-35143 / NCI NIH HHS
Language: English
Date published: 09/14/2024
Academic Unit: Epidemiology
Record Identifier: 9984719802302771

Metrics

9 Record Views