Journal article
Traceless Directing Group for Stereospecific Nickel-Catalyzed Alkyl−Alkyl Cross-Coupling Reactions
Organic letters, Vol.14(16), pp.4293-4296
08/17/2012
DOI: 10.1021/ol300891k
PMID: 22568515
Abstract
Stereospecific nickel-catalyzed cross-coupling reactions of benzylic 2-methoxyethyl ethers are reported for the preparation of enantioenriched 1,1-diarylethanes. The 2-methoxyethyl ether serves as a traceless directing group that accelerates cross-coupling. Chelation of magnesium ions is proposed to activate the benzylic C-O bond for oxidative addition.
Details
- Title: Subtitle
- Traceless Directing Group for Stereospecific Nickel-Catalyzed Alkyl−Alkyl Cross-Coupling Reactions
- Creators
- Margaret A Greene - Department of Chemistry, University of California, Irvine, California 92697-2025, United StatesIvelina M Yonova - Department of Chemistry, University of California, Irvine, California 92697-2025, United StatesFlorence J Williams - Department of Chemistry, University of California, Irvine, California 92697-2025, United StatesElizabeth R Jarvo - Department of Chemistry, University of California, Irvine, California 92697-2025, United States
- Resource Type
- Journal article
- Publication Details
- Organic letters, Vol.14(16), pp.4293-4296
- DOI
- 10.1021/ol300891k
- PMID
- 22568515
- ISSN
- 1523-7060
- eISSN
- 1523-7052
- Language
- English
- Date published
- 08/17/2012
- Academic Unit
- Iowa Neuroscience Institute; Chemistry
- Record Identifier
- 9984070597102771
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