Journal article
Tracheal allograft reconstruction: the total North American and worldwide pediatric experiences
The Annals of thoracic surgery, Vol.68(3), pp.1043-1051
1999
DOI: 10.1016/S0003-4975(99)00878-4
PMID: 10510005
Abstract
Background. We reviewed both the North American and the total worldwide pediatric experience with tracheal allograft reconstruction as treatment for patients with long segment and recurrent tracheal stenosis.
Methods. The stenosed tracheal segment is opened to widely patent segments. The anterior cartilage is resected and the posterior trachealis muscle or tracheal wall remains. A temporary silastic intraluminal stent is placed and absorbable sutures secure the chemically preserved cadaveric trachea. After initial success with this technique in Europe, several North American centers have now performed the procedure. The cumulative North American experience includes 6 patients (3 adults and 3 children). Worldwide, more than 100 adults and 31 children, aged 5 months to 18 years, with severe long segment tracheal stenosis have undergone tracheal allograft reconstruction.
Results. In North America, 5 of 6 patients have survived, with one early death due to bleeding from a tracheal-innominate artery fistula in a previously irradiated neck. Worldwide, 26 children survived (26 of 31 = 84%) with follow-up from 5 months to 14 years. Only 1 of 26 pediatric survivors (1 of 26 = 3.8%) had a tracheostomy.
Conclusions. Tracheal allograft reconstruction demonstrates encouraging short- to medium-term results for patients with complex tracheal stenosis. Allograft luminal epithelialization supports the expectation of good long-term results.
Details
- Title: Subtitle
- Tracheal allograft reconstruction: the total North American and worldwide pediatric experiences
- Creators
- Jeffrey P Jacobs - University of South FloridaJames A Quintessenza - University of South FloridaTom Andrews - University of South FloridaRedmond P Burke - Boston Children's HospitalZorik Spektor - Boston Children's HospitalRalph E Delius - University of IowaRichard J.H Smith - University of IowaMartin J Elliott - Great Ormond Street HospitalClaus Herberhold - University of Bonn
- Resource Type
- Journal article
- Publication Details
- The Annals of thoracic surgery, Vol.68(3), pp.1043-1051
- Publisher
- Elsevier Inc
- DOI
- 10.1016/S0003-4975(99)00878-4
- PMID
- 10510005
- ISSN
- 0003-4975
- eISSN
- 1552-6259
- Language
- English
- Date published
- 1999
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Molecular Physiology and Biophysics; Anatomy and Cell Biology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Otolaryngology; Internal Medicine
- Record Identifier
- 9984256836702771
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