Tracking Regional Tissue Volume and Function Change in Lung Using Image Registration

Kunlin Cao; Gary E Christensen; Kai Ding; Kaifang Du; Maghavan L Raghavan; Ryan E Amelon; Kimberly M Baker; Eric A Hoffman; Joseph M Reinhardt

doi:10.1155/2012/956248

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Tracking Regional Tissue Volume and Function Change in Lung Using Image Registration

Journal article

Open access

Peer reviewed

Tracking Regional Tissue Volume and Function Change in Lung Using Image Registration

Kunlin Cao, Gary E Christensen, Kai Ding, Kaifang Du, Maghavan L Raghavan, Ryan E Amelon, Kimberly M Baker, Eric A Hoffman and Joseph M Reinhardt

International journal of biomedical imaging, Vol.2012, 956248

2012

DOI: 10.1155/2012/956248

PMCID: PMC3483832

PMID: 23118740

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https://doi.org/10.1155/2012/956248View

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Abstract

We have previously demonstrated the 24-hour redistribution and reabsorption of bronchoalveolar lavage (BAL) fluid delivered to the lung during a bronchoscopic procedure in normal volunteers. In this work we utilize image-matching procedures to correlate fluid redistribution and reabsorption to changes in regional lung function. Lung CT datasets from six human subjects were used in this study. Each subject was scanned at four time points before and after BAL procedure. Image registration was performed to align images at different time points and different inflation levels. The resulting dense displacement fields were utilized to track tissue volume changes and reveal deformation patterns of local parenchymal tissue quantitatively. The registration accuracy was assessed by measuring landmark matching errors, which were on the order of 1 mm. The results show that quantitative-assessed fluid volume agreed well with bronchoscopist-reported unretrieved BAL volume in the whole lungs (squared linear correlation coefficient was 0.81). The average difference of lung tissue volume at baseline and after 24 hours was around 2%, which indicates that BAL fluid in the lungs was almost absorbed after 24 hours. Regional lung-function changes correlated with the presence of BAL fluid, and regional function returned to baseline as the fluid was reabsorbed.

Details

Title: Subtitle: Tracking Regional Tissue Volume and Function Change in Lung Using Image Registration
Creators: Kunlin Cao - General Electric (United States)
Gary E Christensen - University of Iowa
Kai Ding - Virginia Commonwealth University
Kaifang Du - University of Iowa
Maghavan L Raghavan - University of Iowa
Ryan E Amelon - University of Iowa
Kimberly M Baker - University of Iowa
Eric A Hoffman - University of Iowa
Joseph M Reinhardt - University of Iowa
Resource Type: Journal article
Publication Details: International journal of biomedical imaging, Vol.2012, 956248
DOI: 10.1155/2012/956248
PMID: 23118740
PMCID: PMC3483832
NLM abbreviation: Int J Biomed Imaging
ISSN: 1687-4188
eISSN: 1687-4196
Grant note: DOI: 10.13039/100000002, name: National Institutes of Health, award: HL079406, HL64368, HL080285, EB004126, CA129022
Language: English
Date published: 2012
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Pulmonary, Critical Care, and Occupational Medicine; Iowa Technology Institute; Radiation Oncology; Radiation Research Laboratory; The Iowa Institute for Biomedical Imaging; Advanced Pulmonary Physiomic Imaging Laboratory; Holden Comprehensive Cancer Center; Internal Medicine
Record Identifier: 9984196978202771

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