Tracking stem cells with superparamagnetic iron oxide nanoparticles: perspectives and considerations

Jasmin; Gustavo Torres de Souza; Ruy Andrade Louzada; Paulo Henrique Rosado-de-Castro; Rosalia Mendez-Otero; Antonio Carlos Campos de Carvalho

doi:10.2147/IJN.S126530

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Tracking stem cells with superparamagnetic iron oxide nanoparticles: perspectives and considerations

Journal article

Open access

Peer reviewed

Tracking stem cells with superparamagnetic iron oxide nanoparticles: perspectives and considerations

Jasmin, Gustavo Torres de Souza, Ruy Andrade Louzada, Paulo Henrique Rosado-de-Castro, Rosalia Mendez-Otero and Antonio Carlos Campos de Carvalho

International journal of nanomedicine, Vol.12, pp.779-793

01/01/2017

DOI: 10.2147/IJN.S126530

PMCID: PMC5279820

PMID: 28182122

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Abstract

Superparamagnetic iron oxide nanoparticles (SPIONs) have been used for diagnoses in biomedical applications, due to their unique properties and their apparent safety for humans. In general, SPIONs do not seem to produce cell damage, although their long-term in vivo effects continue to be investigated. The possibility of efficiently labeling cells with these magnetic nanoparticles has stimulated their use to noninvasively track cells by magnetic resonance imaging after transplantation. SPIONs are attracting increasing attention and are one of the preferred methods for cell labeling and tracking in preclinical and clinical studies. For clinical protocol approval of magnetic-labeled cell tracking, it is essential to expand our knowledge of the time course of SPIONs after cell incorporation and transplantation. This review focuses on the recent advances in tracking SPION-labeled stem cells, analyzing the possibilities and limitations of their use, not only focusing on myocardial infarction but also discussing other models.

Life Sciences & Biomedicine

Nanoscience & Nanotechnology

Pharmacology & Pharmacy

Science & Technology

Science & Technology - Other Topics

Details

Title: Subtitle: Tracking stem cells with superparamagnetic iron oxide nanoparticles: perspectives and considerations
Creators: Jasmin - Univ Fed Rio de Janeiro, NUMPEX Bio, Duque De Caxias, RJ, Brazil
Gustavo Torres de Souza - Universidade Federal de Juiz de Fora
Ruy Andrade Louzada - Université Paris-Sud
Paulo Henrique Rosado-de-Castro - Universidade Federal do Rio de Janeiro
Rosalia Mendez-Otero - Universidade Federal do Rio de Janeiro
Antonio Carlos Campos de Carvalho - Univ Fed Rio de Janeiro, Inst Carlos Chagas Filho Biophys, Rio De Janeiro, RJ, Brazil
Resource Type: Journal article
Publication Details: International journal of nanomedicine, Vol.12, pp.779-793
DOI: 10.2147/IJN.S126530
PMID: 28182122
PMCID: PMC5279820
NLM abbreviation: Int J Nanomedicine
ISSN: 1178-2013
eISSN: 1178-2013
Publisher: Dove Medical Press Ltd
Number of pages: 15
Grant note: Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq); Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ) Fundacao de Amparo a Pesquisa do Estado do Rio de Janeiro (FAPERJ); Fundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio De Janeiro (FAPERJ)
Language: English
Date published: 01/01/2017
Academic Unit: Radiology
Record Identifier: 9985143124302771

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