Traditional Mexican dietary pattern and cancer risk among women of Mexican descent

Nicole C Loroña; Margarita Santiago-Torres; Melissa Lopez-Pentecost; Lorena Garcia; Aladdin H Shadyab; Yangbo Sun; Candyce H Kroenke; Linda G Snetselaar; Marcia L Stefanick; Marian L Neuhouser

doi:10.1007/s10552-024-01849-5

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Traditional Mexican dietary pattern and cancer risk among women of Mexican descent

Journal article

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Traditional Mexican dietary pattern and cancer risk among women of Mexican descent

Nicole C Loroña, Margarita Santiago-Torres, Melissa Lopez-Pentecost, Lorena Garcia, Aladdin H Shadyab, Yangbo Sun, Candyce H Kroenke, Linda G Snetselaar, Marcia L Stefanick and Marian L Neuhouser

Cancer causes & control, Vol.35(6), pp.887-896

06/2024

DOI: 10.1007/s10552-024-01849-5

PMCID: PMC11129927

PMID: 38305935

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Abstract

To examine the association of a traditional Mexican diet score with risk of total, breast, and colorectal cancer among women of Mexican ethnic descent in the Women's Health Initiative (WHI). Participants were WHI enrollees who self-identified as being of Mexican descent. Data from food frequency questionnaires self-administered at study baseline were used to calculate the MexD score, with higher scores indicating greater adherence to an a priori-defined traditional Mexican diet (high in dietary fiber, vegetables, and legumes). Incident cancers were self-reported by participants from 1993 to 2020 and adjudicated by trained physicians. We used multivariable-adjusted Cox proportional hazards models to calculate hazard ratios (HRs) and 95% confidence intervals (CIs). Among 2,343 Mexican descent women (median baseline age: 59 years), a total of 270 cancers (88 breast, 37 colorectal) occurred during a mean follow-up of 14.4 years. The highest tertile of MexD score was associated with a lower risk of all-cancer incidence (HR: 0.67; 95% CI 0.49-0.91; p-trend: 0.01) and colorectal cancer (HR: 0.38; 95% CI 0.14-0.998; p-trend < 0.05), with each unit increase in the MexD score associated with a 6% lower risk of all-cancer incidence (HR: 0.94; 95% CI 0.88-0.99). There was no statistically significant association with risk of breast cancer. Consumption of a traditional Mexican diet was associated with a significantly lower risk of all-cancer incidence and colorectal cancer. Confirmation of these findings in future studies is important, given the prevalence of colorectal cancer and a growing U.S. population of women of Mexican descent.

Breast Cancer

Colorectal Cancer

WHI

Mexican diet

Dietary pattern

Cancer risk

Details

Title: Subtitle: Traditional Mexican dietary pattern and cancer risk among women of Mexican descent
Creators: Nicole C Loroña - Fred Hutch Cancer Center
Margarita Santiago-Torres - Fred Hutch Cancer Center
Melissa Lopez-Pentecost - University of Miami
Lorena Garcia - University of California, Davis
Aladdin H Shadyab - University of California San Diego
Yangbo Sun - University of Tennessee Health Science Center
Candyce H Kroenke - Kaiser Permanente
Linda G Snetselaar - University of Iowa
Marcia L Stefanick - Stanford University
Marian L Neuhouser - Fred Hutch Cancer Center
Resource Type: Journal article
Publication Details: Cancer causes & control, Vol.35(6), pp.887-896
DOI: 10.1007/s10552-024-01849-5
PMID: 38305935
PMCID: PMC11129927
NLM abbreviation: Cancer Causes Control
ISSN: 0957-5243
eISSN: 1573-7225
Grant note: T32CA009168 / NIH HHS T32CA251064 / NIH HHS
Language: English
Electronic publication date: 02/02/2024
Date published: 06/2024
Academic Unit: Epidemiology; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
Record Identifier: 9984556559002771

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