Journal article
Trajectories of Relative Performance with 2 Measures of Global Cognitive Function
Journal of the American Geriatrics Society (JAGS), Vol.66(8), pp.1575-1580
08/2018
DOI: 10.1111/jgs.15431
PMCID: PMC6167188
PMID: 29972592
Abstract
To examine whether trajectories of global cognitive function over time in studies that change assessment protocols may be modeled based on an individual's performance relative to others in the study cohort.
Extended follow-up of a cohort originally enrolled in a clinical trial of postmenopausal hormone therapy.
The Women's Health Initiative Memory Study switched from an in-person interview with the Modified Mini-Mental State Examination to a telephone-based interview with the modified Telephone Interview for Cognitive Status to assess global cognitive function over long-term follow-up.
Women aged 75 to 92 (N=2,561).
Annual cognitive assessments from participants, ranked according to age-, race- and ethnicity-adjusted performance levels, were used to identify distinct trajectories. Participants assigned to the resulting trajectories were compared for selected risk factor profiles.
Our approach grouped participants into five trajectories according to relative cognitive performance over time. These groups differed significantly according to 3 known risk factors for cognitive decline-education level, apolipoprotein E-ϵ4 genotype, and type 2 diabetes mellitus-and a biomarker based on brain structure that has been linked to cognitive decline and Alzheimer's disease. Participants with consistently low relative levels of cognitive function over time and those whose relative performance over time declined to these levels tended to have poorer risk factor profiles.
Longitudinal measures of an individual's relative performance on different assessment protocols for global cognitive function can be used to identify trajectories of change over time that appear to have internal validity with respect to known risk factors.
Details
- Title: Subtitle
- Trajectories of Relative Performance with 2 Measures of Global Cognitive Function
- Creators
- Mark A Espeland - Wake Forest UniversityJiu-Chiuan Chen - University of Southern CaliforniaJulie Weitlauf - VA Palo Alto Health Care SystemKathleen M Hayden - Wake Forest UniversityStephen R Rapp - Wake Forest UniversitySusan M Resnick - National Institute on AgingLorena Garcia - University of California, DavisBrad Cannell - University of North Texas Health Science CenterLaura D Baker - Wake Forest UniversityBonnie C Sachs - Wake Forest UniversityHilary A Tindle - Vanderbilt UniversityRobert Wallace - University of IowaRamon Casanova - Wake Forest UniversityWomen's Health Initiative Memory Study Magnetic Resonance Imaging Study Group
- Resource Type
- Journal article
- Publication Details
- Journal of the American Geriatrics Society (JAGS), Vol.66(8), pp.1575-1580
- DOI
- 10.1111/jgs.15431
- PMID
- 29972592
- PMCID
- PMC6167188
- NLM abbreviation
- J Am Geriatr Soc
- ISSN
- 0002-8614
- eISSN
- 1532-5415
- Grant note
- N01 WH044221 / WHI NIH HHS NIA Contract HHSN271201700002C. / NIH HHS P30 AG049638-01A1 / NIH HHS R01 ES025888 / NIEHS NIH HHS P30 AG049638 / NIA NIH HHS R21 AG051113 / NIA NIH HHS 1 R21 AG051113 / NIH HHS HHSN268201600004C / NIH HHS HHSN268201100004C / WHI NIH HHS
- Language
- English
- Date published
- 08/2018
- Academic Unit
- Epidemiology; Injury Prevention Research Center; Internal Medicine
- Record Identifier
- 9984363585902771
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