Trajectories of inflammatory markers and cognitive decline over 10 years

Andrea L Metti; Kristine Yaffe; Robert M Boudreau; Eleanor M Simonsick; Ryan M Carnahan; Suzanne Satterfield; Tamara B Harris; Hilsa N Ayonayon; Caterina Rosano; Jane A Cauley; Health ABC Study

doi:10.1016/j.neurobiolaging.2014.05.030

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Trajectories of inflammatory markers and cognitive decline over 10 years

Journal article

Peer reviewed

Trajectories of inflammatory markers and cognitive decline over 10 years

Andrea L Metti, Kristine Yaffe, Robert M Boudreau, Eleanor M Simonsick, Ryan M Carnahan, Suzanne Satterfield, Tamara B Harris, Hilsa N Ayonayon, Caterina Rosano, Jane A Cauley, …

Neurobiology of aging, Vol.35(12), pp.2785-2790

12/2014

DOI: 10.1016/j.neurobiolaging.2014.05.030

PMCID: PMC4252870

PMID: 24997674

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Abstract

We aimed to examine trajectories of inflammatory markers and cognitive decline over 10 years. Cox proportional hazards models were used to examine the association between interleukin-6 and C-reactive protein (CRP) trajectory components (slope, variability, and baseline level) and cognitive decline among 1323 adults, aged 70–79 years in the Health, Aging, and Body Composition Study. We tested for interactions by sex and apolipoprotein E (APOE) genotype. In models adjusted for multiple covariates and comorbidities, extreme CRP variability was significantly associated with cognitive decline (hazard ratio [HR] 1.6, 95% confidence interval [CI]: 1.1–2.3). This association was modified by sex and APOE e4 (p < 0.001 for both), such that the association remained among women (HR = 1.8; 95% CI: 1.1, 3.0) and among those with no APOE e4 allele (HR = 1.6; 95% CI: 1.1, 2.5). There were no significant associations between slope or baseline level of CRP and cognitive decline nor between interleukin-6 and cognitive decline. We believe CRP variability likely reflects poor control of or greater changes in vascular or metabolic disease over time, which in turn is associated with cognitive decline. •We used a prospective to examine the association between trajectories of inflammatory markers, C-reactive protein (CRP) and interleukin-6, and cognitive decline.•Extreme variability in CRP over time was associated with an increased risk of incident cognitive decline.•This association was stronger among women and those who had no apolipoprotein e4 allele. There was no significant association between baseline CRP level or CRP slope and incident cognitive decline.•There were no significant associations between any trajectory patterns of interleukin-6 and incident cognitive decline.

Cognitive decline

Inflammatory markers

C-reactive protein

Interleukin-6

Details

Title: Subtitle: Trajectories of inflammatory markers and cognitive decline over 10 years
Creators: Andrea L Metti - Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
Kristine Yaffe - Department of Psychiatry, University of California San Francisco, San Francisco, CA, USA
Robert M Boudreau - Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
Eleanor M Simonsick - Clinical Research Branch, National Institute on Aging, Baltimore, MD, USA
Ryan M Carnahan - Department of Epidemiology, The University of Iowa College of Public Health, Iowa City, IA, USA
Suzanne Satterfield - Department of Preventive Medicine, University of Tennessee, Memphis, TN, USA
Tamara B Harris - Laboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute on Aging, Bethesda, MD, USA
Hilsa N Ayonayon - Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA
Caterina Rosano - Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
Jane A Cauley - Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
Health ABC Study
Resource Type: Journal article
Publication Details: Neurobiology of aging, Vol.35(12), pp.2785-2790
DOI: 10.1016/j.neurobiolaging.2014.05.030
PMID: 24997674
PMCID: PMC4252870
NLM abbreviation: Neurobiol Aging
ISSN: 0197-4580
eISSN: 1558-1497
Publisher: Elsevier Inc
Grant note: DOI: 10.13039/100000049, name: National Institute on Aging, award: N01-AG-6-2101, N01-AG-6-2103, N01-AG-6-2106; DOI: 10.13039/100000049, name: National Institute on Aging, award: R01-AG028050; DOI: 10.13039/100000056, name: National Institute of Nursing Research, award: R01-NR012459; name: National Institutes of Health Training, award: 2T32AG000181
Language: English
Date published: 12/2014
Academic Unit: Epidemiology; Injury Prevention Research Center
Record Identifier: 9983996097102771

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