Trans Fatty Acid Biomarkers and Incident Type 2 Diabetes: Pooled Analysis of 12 Prospective Cohort Studies in the Fatty Acids and Outcomes Research Consortium (FORCE)

Heidi T M Lai; Fumiaki Imamura; Andres V Ardisson Korat; Rachel A Murphy; Nathan Tintle; Julie K Bassett; Jiaying Chen; Janine Kröger; Kuo-Liong Chien; Mackenzie Senn; Alexis C Wood; Nita G Forouhi; Matthias B Schulze; William S Harris; Ramachandran S Vasan; Frank Hu; Graham G Giles; Allison Hodge; Luc Djousse; Ingeborg A Brouwer; Frank Qian; Qi Sun; Jason H Y Wu; Matti Marklund; Rozenn N Lemaitre; David S Siscovick; Amanda M Fretts; Aladdin H Shadyab; JoAnn E Manson; Barbara V Howard; Jennifer G Robinson; Robert B Wallace; Nick J Wareham; Yii-Der Ida Chen; Jerome I Rotter; Michael Y Tsai; Renata Micha; Dariush Mozaffarian; Fatty Acids and Outcomes Research Consortium (FORCE)

doi:10.2337/dc21-1756

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Trans Fatty Acid Biomarkers and Incident Type 2 Diabetes: Pooled Analysis of 12 Prospective Cohort Studies in the Fatty Acids and Outcomes Research Consortium (FORCE)

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Trans Fatty Acid Biomarkers and Incident Type 2 Diabetes: Pooled Analysis of 12 Prospective Cohort Studies in the Fatty Acids and Outcomes Research Consortium (FORCE)

Heidi T M Lai, Fumiaki Imamura, Andres V Ardisson Korat, Rachel A Murphy, Nathan Tintle, Julie K Bassett, Jiaying Chen, Janine Kröger, Kuo-Liong Chien, Mackenzie Senn, …

Diabetes care, Vol.45(4), pp.854-863

04/01/2022

DOI: 10.2337/dc21-1756

PMCID: PMC9114723

PMID: 35142845

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Abstract

Trans fatty acids (TFAs) have harmful biologic effects that could increase the risk of type 2 diabetes (T2D), but evidence remains uncertain. We aimed to investigate the prospective associations of TFA biomarkers and T2D by conducting an individual participant-level pooled analysis. We included data from an international consortium of 12 prospective cohorts and nested case-control studies from six nations. TFA biomarkers were measured in blood collected between 1990 and 2008 from 25,126 participants aged ≥18 years without prevalent diabetes. Each cohort conducted de novo harmonized analyses using a prespecified protocol, and findings were pooled using inverse-variance weighted meta-analysis. Heterogeneity was explored by prespecified between-study and within-study characteristics. During a mean follow-up of 13.5 years, 2,843 cases of incident T2D were identified. In multivariable-adjusted pooled analyses, no significant associations with T2D were identified for trans/trans-18:2, relative risk (RR) 1.09 (95% CI 0.94-1.25); cis/trans-18:2, 0.89 (0.73-1.07); and trans/cis-18:2, 0.87 (0.73-1.03). Trans-16:1n-9, total trans-18:1, and total trans-18:2 were inversely associated with T2D (RR 0.81 [95% CI 0.67-0.99], 0.86 [0.75-0.99], and 0.84 [0.74-0.96], respectively). Findings were not significantly different according to prespecified sources of potential heterogeneity (each P ≥ 0.1). Circulating individual trans-18:2 TFA biomarkers were not associated with risk of T2D, while trans-16:1n-9, total trans-18:1, and total trans-18:2 were inversely associated. Findings may reflect the influence of mixed TFA sources (industrial vs. natural ruminant), a general decline in TFA exposure due to policy changes during this period, or the relatively limited range of TFA levels.

Adolescent

Adult

Biomarkers

Cohort Studies

Diabetes Mellitus, Type 2 - epidemiology

Fatty Acids

Humans

Outcome Assessment, Health Care

Prospective Studies

Risk Factors

Trans Fatty Acids - adverse effects

Details

Title: Subtitle: Trans Fatty Acid Biomarkers and Incident Type 2 Diabetes: Pooled Analysis of 12 Prospective Cohort Studies in the Fatty Acids and Outcomes Research Consortium (FORCE)
Creators: Heidi T M Lai - Imperial College London
Fumiaki Imamura - MRC Epidemiology Unit
Andres V Ardisson Korat - Brigham and Women's Hospital
Rachel A Murphy - University of British Columbia
Nathan Tintle - Dordt University
Julie K Bassett - Cancer Council Victoria
Jiaying Chen - Brigham and Women's Hospital
Janine Kröger - German Institute of Human Nutrition
Kuo-Liong Chien - National Taiwan University
Mackenzie Senn - Baylor College of Medicine
Alexis C Wood - Baylor College of Medicine
Nita G Forouhi - MRC Epidemiology Unit
Matthias B Schulze - University of Potsdam
William S Harris - University of South Dakota
Ramachandran S Vasan - Boston University
Frank Hu - Brigham and Women's Hospital
Graham G Giles - Monash University
Allison Hodge - Cancer Council Victoria
Luc Djousse - Brigham and Women's Hospital
Ingeborg A Brouwer - Vrije Universiteit Amsterdam
Frank Qian - Harvard University
Qi Sun - Brigham and Women's Hospital
Jason H Y Wu - The George Institute for Global Health
Matti Marklund - Tufts University
Rozenn N Lemaitre - University of Washington
David S Siscovick - The New York Academy of Medicine, New York, NY.
Amanda M Fretts - University of Washington
Aladdin H Shadyab - University of California San Diego
JoAnn E Manson - Harvard University
Barbara V Howard - Georgetown University Medical Center
Jennifer G Robinson - University of Iowa
Robert B Wallace - University of Iowa
Nick J Wareham - University of Cambridge
Yii-Der Ida Chen - The Lundquist Institute
Jerome I Rotter - The Lundquist Institute
Michael Y Tsai - University of Minnesota
Renata Micha - Tufts University
Dariush Mozaffarian - Tufts University
Fatty Acids and Outcomes Research Consortium (FORCE)
Resource Type: Journal article
Publication Details: Diabetes care, Vol.45(4), pp.854-863
DOI: 10.2337/dc21-1756
PMID: 35142845
PMCID: PMC9114723
NLM abbreviation: Diabetes Care
ISSN: 1935-5548
eISSN: 1935-5548
Grant note: R01 HL115189 / NHLBI NIH HHS MC_UU_00006/3 / Medical Research Council T32 CA009001 / NCI NIH HHS MC_UU_00006/1 / Medical Research Council UM1 CA186107 / NCI NIH HHS R01 HL060712 / NHLBI NIH HHS
Language: English
Date published: 04/01/2022
Academic Unit: Epidemiology; Fraternal Order of Eagles Diabetes Research Center; Injury Prevention Research Center; Internal Medicine
Record Identifier: 9984364407302771

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