Journal article
Trans fatty acids in maternal milk lead to cardiac insulin resistance in adult offspring
Nutrition (Burbank, Los Angeles County, Calif.), Vol.24(7), pp.727-732
07/01/2008
DOI: 10.1016/j.nut.2008.03.006
PMID: 18499400
Abstract
Trans fatty acids (TFAs) are derived from vegetable oil hydrogenation and can be found in most manufactured food products. Our main objective was to evaluate the effects of TFA consumption by lactating dams on cardiac glucose metabolism of adult offspring by analyzing glucose transporter-4 in the left ventricle. To investigate the energy homeostasis, insulin sensitivity and hepatic glycogen content were also measured.
Lactating Wistar rats were divided into a control group or a TFA group. The control group received a diet containing soybean oil, and the TFA group received a diet containing partially hydrogenated vegetable oil (total
trans concentration of about 10.58 mg/g, 11.75%, of total fat) throughout the lactation period. At weaning, pups from both groups received a standard chow until 60 d of age, at which time the quantity of glucose transporter-4 in the left ventricle and hepatic glycogen were measured. Moreover, insulin sensitivity was analyzed by assessing the insulin/glucose ratio and the homeostatic model assessment index.
TFA consumption by the pups during lactation led to a significant decrease in the cardiac content of glucose transporter-4 (
P < 0.05) and in the hepatic content of glycogen (
P < 0.05). Moreover, we observed impaired insulin sensitivity in the TFA group (insulin/glucose ratio and homeostatic model assessment index,
P < 0.05) in adulthood.
Our data suggest that the consumption of hydrogenated fat, rich in TFAs, by the mothers during the lactation period caused cardiac insulin resistance in the adult progeny, thus reinforcing the hypothesis that early adaptations may cause deleterious consequences later in life.
Details
- Title: Subtitle
- Trans fatty acids in maternal milk lead to cardiac insulin resistance in adult offspring
- Creators
- Fernanda Silveira Osso - Universidade do Estado do Rio de JaneiroAnnie Seixas Bello Moreira - Universidade do Estado do Rio de JaneiroMichelle Teixeira Teixeira - Universidade do Estado do Rio de JaneiroRenata Oliveira Pereira - Laboratory of Nutrition and Developmental Physiology, Department of Physiology, State University of Rio de Janeiro, Rio de Janeiro, BrazilMaria das Graças Tavares do Carmo - Universidade Federal do Rio de JaneiroAníbal Sanchez Moura - Universidade do Estado do Rio de Janeiro
- Resource Type
- Journal article
- Publication Details
- Nutrition (Burbank, Los Angeles County, Calif.), Vol.24(7), pp.727-732
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.nut.2008.03.006
- PMID
- 18499400
- ISSN
- 0899-9007
- eISSN
- 1873-1244
- Language
- English
- Date published
- 07/01/2008
- Academic Unit
- Fraternal Order of Eagles Diabetes Research Center; Endocrinology and Metabolism; Internal Medicine
- Record Identifier
- 9984420937802771
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