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Transcription Factors in Breast Cancer Oncogenesis and Progression
Journal article   Peer reviewed

Transcription Factors in Breast Cancer Oncogenesis and Progression

Lianna Fiore, Zhijie Li, Collin Montgomery, Audrey Coleman, Colin Kenny and Ronald J Weigel
Molecular and cellular biology
07/04/2026
DOI: 10.1080/10985549.2026.2694520
PMID: 42401990

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Abstract

Gene expression regulated through a set of transcription factors orchestrates the physiologic processes that drive mammary gland development, breast cancer oncogenesis, and breast cancer progression. This review highlights recent progress in our understanding of how transcriptional regulators mediate mammary gland development, mammary oncogenesis and maintenance of breast cancer stem cells, breast cancer phenotype, metastasis, and efforts to target transcription factors as a therapeutic approach in breast cancer.
Transcription Metastasis Breast Cancer hormone response mammary gland development cancer stem cell mammary oncogenesis

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