Journal article
Transcriptional and Epigenetic Regulation of Effector and Memory CD8 T Cell Differentiation
Frontiers in immunology, Vol.9, pp.2826-2826
2018
DOI: 10.3389/fimmu.2018.02826
PMCID: PMC6292868
PMID: 30581433
Abstract
Immune protection and lasting memory are accomplished through the generation of phenotypically and functionally distinct CD8 T cell subsets. Understanding how these effector and memory T cells are formed is the first step in eventually manipulating the immune system for therapeutic benefit. In this review, we will summarize the current understanding of CD8 T cell differentiation upon acute infection, with a focus on the transcriptional and epigenetic regulation of cell fate decision and memory formation. Moreover, we will highlight the importance of high throughput sequencing approaches and single cell technologies in providing insight into genome-wide investigations and the heterogeneity of individual CD8 T cells.
Details
- Title: Subtitle
- Transcriptional and Epigenetic Regulation of Effector and Memory CD8 T Cell Differentiation
- Creators
- Yao Chen - Medical College of WisconsinRyan Zander - Versiti Blood Center of WisconsinAchia Khatun - Medical College of WisconsinDavid M Schauder - Medical College of WisconsinWeiguo Cui - Medical College of Wisconsin
- Resource Type
- Journal article
- Publication Details
- Frontiers in immunology, Vol.9, pp.2826-2826
- DOI
- 10.3389/fimmu.2018.02826
- PMID
- 30581433
- PMCID
- PMC6292868
- NLM abbreviation
- Front Immunol
- ISSN
- 1664-3224
- eISSN
- 1664-3224
- Grant note
- F30 DK108557 / NIDDK NIH HHS R01 AI125741 / NIAID NIH HHS T32 GM080202 / NIGMS NIH HHS
- Language
- English
- Date published
- 2018
- Academic Unit
- Microbiology and Immunology
- Record Identifier
- 9984297428202771
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