Journal article
Transcriptional control of multidrug resistance in the yeast Saccharomyces
Progress in nucleic acid research and molecular biology, Vol.73, pp.251-279
2003
DOI: 10.1016/S0079-6603(03)01008-0
PMID: 12882520
Abstract
A major problem in chemotherapeutic treatment of many pathological conditions including cancer and fungal infections is the development of a multidrug-resistant state in the target cell. Saccharomyces cerevisiae cells can be isolated that have single genetic alterations that cause the resulting mutant strains to become tolerant of a wide range of compounds that would otherwise be toxic. These mutant cells are referred to as having a pleiotropic drug-resistant (Pdr) phenotype. Studies of these Pdr cells have demonstrated that mutations either within genes encoding transcriptional regulators or in their regulatory inputs lead to overexpression of downstream transporter proteins with associated multidrug resistance. This review is aimed at providing a framework for understanding the networks modulating expression of PDR genes in S. cerevisiae.
Details
- Title: Subtitle
- Transcriptional control of multidrug resistance in the yeast Saccharomyces
- Creators
- W Scott Moye-Rowley - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Progress in nucleic acid research and molecular biology, Vol.73, pp.251-279
- DOI
- 10.1016/S0079-6603(03)01008-0
- PMID
- 12882520
- ISSN
- 0079-6603
- Grant note
- GM49825 / NIGMS NIH HHS
- Language
- English
- Date published
- 2003
- Academic Unit
- Molecular Physiology and Biophysics; Internal Medicine
- Record Identifier
- 9984297597102771
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