Journal article
Transcriptional regulation of the Pseudomonas aeruginosa type III secretion system
Molecular microbiology, Vol.62(3), pp.631-640
11/2006
DOI: 10.1111/j.1365-2958.2006.05412.x
PMID: 16995895
Abstract
Type III secretion systems (T3SS) function by translocating effector proteins into eukaryotic host cells and are important for the virulence of many Gram-negative bacterial pathogens. Although the secretion and translocation machineries are highly conserved between different species, each pathogen translocates a unique set of effectors that subvert normal host cell physiology to promote pathogenesis. The uniqueness of each pathogen is further reflected in the diversity of mechanisms used to regulate T3SS gene expression. Pseudomonas aeruginosa utilizes a complex set of signalling pathways to modulate T3SS expression in response to extracellular and intracellular cues. Whereas some pathways are dedicated solely to regulating the T3SS, others co-ordinately regulate expression of the T3SS with multiple virulence functions on a global scale. Emerging regulatory themes include coupling of T3SS transcription with type III secretory activity, global regulatory control through modulation of cAMP biosynthesis, repression by a variety of stresses, involvement of multiple two component regulatory systems, and an inverse relationship between T3SS expression and multicellular behaviour. Factors controlling activation of T3SS expression likely contribute to the environmental survival of the organism and to the pathogenesis of acute P. aeruginosa infections. Conversely, active repression of the T3SS might contribute to the persistence of chronic infections.
Details
- Title: Subtitle
- Transcriptional regulation of the Pseudomonas aeruginosa type III secretion system
- Creators
- Timothy L Yahr - University of Iowa, Department of Microbiology, Iowa City, IA, USA. timothy-yahr@uiowa.eduMatthew C Wolfgang
- Resource Type
- Journal article
- Publication Details
- Molecular microbiology, Vol.62(3), pp.631-640
- Publisher
- England
- DOI
- 10.1111/j.1365-2958.2006.05412.x
- PMID
- 16995895
- ISSN
- 0950-382X
- eISSN
- 1365-2958
- Grant note
- R01-AI055042 / NIAID NIH HHS R01 AI055042 / NIAID NIH HHS
- Language
- English
- Date published
- 11/2006
- Academic Unit
- Microbiology and Immunology
- Record Identifier
- 9984001213702771
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