Journal article
Transcriptome changes in age-related macular degeneration
BMC medicine, Vol.10(1), pp.21-21
02/27/2012
DOI: 10.1186/1741-7015-10-21
PMCID: PMC3307472
PMID: 22369667
Abstract
Age-related macular degeneration (AMD) is a debilitating, common cause of visual impairment. While the last decade has seen great progress in understanding the pathophysiology of AMD, the molecular changes that occur in eyes with AMD are still poorly understood. In the current issue of Genome Medicine, Newman and colleagues present the first systematic transcriptional profile analysis of AMD-affected tissues, providing a comprehensive set of expression data for different regions (macula versus periphery), tissues (retina versus retinal pigment epithelium (RPE)/choroid), and disease state (control versus early or advanced AMD). Their findings will serve as a foundation for additional systems-level research into the pathogenesis of this blinding disease.
Details
- Title: Subtitle
- Transcriptome changes in age-related macular degeneration
- Creators
- S Scott Whitmore - Department of Ophthalmology and Visual Sciences, The University of Iowa Carver College of Medicine, 4135E MERF, 375 Newton Rd, Iowa City, IA 52242, USARobert F Mullins
- Resource Type
- Journal article
- Publication Details
- BMC medicine, Vol.10(1), pp.21-21
- DOI
- 10.1186/1741-7015-10-21
- PMID
- 22369667
- PMCID
- PMC3307472
- NLM abbreviation
- BMC Med
- ISSN
- 1741-7015
- eISSN
- 1741-7015
- Publisher
- England
- Grant note
- 5T32GM082729-03 / NIGMS NIH HHS T32 GM008629 / NIGMS NIH HHS EY017451 / NEI NIH HHS
- Language
- English
- Date published
- 02/27/2012
- Academic Unit
- Ophthalmology and Visual Sciences
- Record Identifier
- 9983980020402771
Metrics
16 Record Views