Transcutaneous Oximetry May Predict Wound Healing Complications In Preoperatively Radiated Soft Tissue Sarcoma

Lukas M Nystrom; Benjamin J Miller

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Transcutaneous Oximetry May Predict Wound Healing Complications In Preoperatively Radiated Soft Tissue Sarcoma

Journal article

Open access

Peer reviewed

Transcutaneous Oximetry May Predict Wound Healing Complications In Preoperatively Radiated Soft Tissue Sarcoma

Lukas M Nystrom and Benjamin J Miller

The Iowa orthopaedic journal, Vol.36, pp.117-122

2016

PMCID: PMC4910776

PMID: 27528847

Appears in Diamond Open Access

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url

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910776/View

Published (Version of record) Open Access

Abstract

Preoperative radiation is frequently used in management of soft tissue sarcoma. We hypothesize that anoxic tissue from preoperative radiation contributes to surgical wound complications and that transcutaneous oximetry (TcO2) measurements made preoperatively can predict wounds at risk. Ten consecutive patients were prospectively enrolled. TcO2 was recorded at five time points. Wound complications (defined as major or minor) and healing outcomes were recorded out to 120 days postoperatively. Means between groups with and without wound complications were compared by use of a Student's t-test (p < 0.05). There were three major and one minor wound complication. During the time from radiation to surgery, patients with wound complications had a 13.1 mmHg decrease in mean TcO2 while those who healed uneventfully had an increase of 2.3 mm Hg (p=0.09). Patients with complications had a low preoperative TcO2 of 18.7 mmHg compared to those without complications (18.7 vs. 33.4 mmHg; p=0.09). No patient with a TcO2 greater than 25 mmHg immediately preoperatively developed a wound complication. This data suggests an earlier recovery of tissue oxygenation in patients that healed without complication. The TcO2 measurement immediately preceding surgery seems to be the most important in predicting wound complications. Larger scale investigation may determine if TcO2 measurement is a viable clinical tool to aid in risk assessment for potential wound complications.

Surgical Flaps

Humans

Middle Aged

Male

Blood Gas Monitoring, Transcutaneous

Postoperative Complications - diagnosis

Preoperative Care

Young Adult

Pilot Projects

Soft Tissue Neoplasms - radiotherapy

Soft Tissue Neoplasms - surgery

Neoadjuvant Therapy - adverse effects

Radiotherapy, Adjuvant - adverse effects

Sarcoma - surgery

Adult

Female

Aged

Wound Healing - physiology

Sarcoma - radiotherapy

Details

Title: Subtitle: Transcutaneous Oximetry May Predict Wound Healing Complications In Preoperatively Radiated Soft Tissue Sarcoma
Creators: Lukas M Nystrom
Benjamin J Miller
Resource Type: Journal article
Publication Details: The Iowa orthopaedic journal, Vol.36, pp.117-122
Publisher: Dept. of Orthopaedics, The University of Iowa; United States
PMID: 27528847
PMCID: PMC4910776
ISSN: 1541-5457
eISSN: 1555-1377
Grant note: P30 CA086862 / NCI NIH HHS
Language: English
Date published: 2016
Academic Unit: Orthopedics and Rehabilitation
Record Identifier: 9984040585002771

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