Journal article
Transcutaneous electrical nerve stimulation (TENS) reduces chronic hyperalgesia induced by muscle inflammation
Pain (Amsterdam), Vol.120(1), pp.182-187
2006
DOI: 10.1016/j.pain.2005.10.030
PMID: 16360266
Abstract
Transcutaneous electrical nerve stimulation (TENS) reduces pain through central mechanisms involving spinal cord and brainstem sites. Since TENS acts through central mechanisms, we hypothesized that TENS will reduce chronic bilateral hyperalgesia produced by unilateral inflammation when applied either ipsilateral or contralateral to the site of muscle inflammation. Sprague–Dawley rats were injected with carrageenan in the left gastrocnemius muscle belly. Mechanical withdrawal threshold was tested bilaterally before and 2 weeks after carrageenan injection. After testing withdrawal thresholds at 2 weeks, rats received TENS treatment either ipsilateral or contralateral to the site of inflammation. In each of these groups, rats were randomized to control (no TENS), low frequency (4
Hz), or high frequency (100
Hz) TENS treatment. TENS was applied for 20
min at sensory intensity under light halothane anesthesia. Mechanical withdrawal thresholds were re-assessed after TENS or ‘no TENS’ treatment. Unilateral injection of carrageenan to the gastrocnemius muscle significantly reduced the mechanical withdrawal threshold (mechanical hyperalgesia) bilaterally 2 weeks later. Either low or high frequency TENS applied to the gastrocnemius muscle ipsilateral to the site of inflammation significantly reversed mechanical hyperalgesia, both ipsilateral and contralateral to the site of inflammation. Low or high frequency TENS applied to the gastrocnemius muscle contralateral to the site of inflammation also significantly reduced mechanical hyperalgesia, both ipsilateral and contralateral to the site of inflammation. Since ipsilateral or contralateral TENS treatments were effective in reducing chronic bilateral hyperalgesia in this animal model, we suggest that TENS act through modulating descending influences from supraspinal sites such as rostral ventromedial medulla (RVM).
Details
- Title: Subtitle
- Transcutaneous electrical nerve stimulation (TENS) reduces chronic hyperalgesia induced by muscle inflammation
- Creators
- Lisa Ainsworth - Graduate Program of Physical Therapy and Rehabilitation Science, University of Iowa, Iowa, IA, USAKendra Budelier - Graduate Program of Physical Therapy and Rehabilitation Science, University of Iowa, Iowa, IA, USAMonica Clinesmith - Graduate Program of Physical Therapy and Rehabilitation Science, University of Iowa, Iowa, IA, USAAbby Fiedler - Graduate Program of Physical Therapy and Rehabilitation Science, University of Iowa, Iowa, IA, USARachel Landstrom - Graduate Program of Physical Therapy and Rehabilitation Science, University of Iowa, Iowa, IA, USAB.J Leeper - Graduate Program of Physical Therapy and Rehabilitation Science, University of Iowa, Iowa, IA, USALeAnn Moeller - Graduate Program of Physical Therapy and Rehabilitation Science, University of Iowa, Iowa, IA, USASarah Mutch - Graduate Program of Physical Therapy and Rehabilitation Science, University of Iowa, Iowa, IA, USAKim O'Dell - Graduate Program of Physical Therapy and Rehabilitation Science, University of Iowa, Iowa, IA, USAJaclyn Ross - Graduate Program of Physical Therapy and Rehabilitation Science, University of Iowa, Iowa, IA, USARajan Radhakrishnan - Graduate Program of Physical Therapy and Rehabilitation Science, University of Iowa, Iowa, IA, USAKathleen A Sluka - Graduate Program of Physical Therapy and Rehabilitation Science, University of Iowa, Iowa, IA, USA
- Resource Type
- Journal article
- Publication Details
- Pain (Amsterdam), Vol.120(1), pp.182-187
- Publisher
- Elsevier B.V
- DOI
- 10.1016/j.pain.2005.10.030
- PMID
- 16360266
- ISSN
- 0304-3959
- eISSN
- 1872-6623
- Language
- English
- Date published
- 2006
- Academic Unit
- Iowa Neuroscience Institute; Nursing; Physical Therapy and Rehabilitation Science; Neuroscience and Pharmacology
- Record Identifier
- 9984040006602771
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