Transcutaneous electrical nerve stimulation, acupuncture, and spinal cord stimulation on neuropathic, inflammatory and, non-inflammatory pain in rat models

Karina Laurenti Sato; Luciana Sayuri Sanada; Morgana Duarte da Silva; Rodrigo Okubo; Kathleen A Sluka

doi:10.3344/kjp.2020.33.2.121

Back

Transcutaneous electrical nerve stimulation, acupuncture, and spinal cord stimulation on neuropathic, inflammatory and, non-inflammatory pain in rat models

Journal article

Open access

Peer reviewed

Transcutaneous electrical nerve stimulation, acupuncture, and spinal cord stimulation on neuropathic, inflammatory and, non-inflammatory pain in rat models

Karina Laurenti Sato, Luciana Sayuri Sanada, Morgana Duarte da Silva, Rodrigo Okubo and Kathleen A Sluka

The Korean journal of pain, Vol.33(2), pp.121-130

04/01/2020

DOI: 10.3344/kjp.2020.33.2.121

PMCID: PMC7136295

PMID: 32235012

Files and links (1)

url

https://doi.org/10.3344/kjp.2020.33.2.121View

Published (Version of record) Open Access

Abstract

Transcutaneous electrical nerve stimulation (TENS), manual acupuncture (MA), and spinal cord stimulation (SCS) are used to treat a variety of pain conditions. These non-pharmacological treatments are often thought to work through similar mechanisms, and thus should have similar effects for different types of pain. However, it is unclear if each of these treatments work equally well on each type of pain condition. The purpose of this study was to compared the effects of TENS, MA, and SCS on neuropathic, inflammatory, and non-inflammatory pain models. TENS 60 Hz, 200 μs, 90% motor threshold (MT), SCS was applied at 60 Hz, an intensity of 90% MT, and a 0.25 ms pulse width. MA was performed by inserting a stainless-steel needle to a depth of about 4-5 mm at the Sanyinjiao (SP6) and Zusanli (ST36) acupoints on a spared nerve injury (SNI), knee joint inflammation (3% carrageenan), and non-inflammatory muscle pain (intramuscular pH 4.0 injections) in rats. Mechanical withdrawal thresholds of the paw, muscle, and/or joint were assessed before and after induction of the pain model, and daily before and after treatment. The reduced withdrawal thresholds were significantly reversed by application of either TENS or SCS ( < 0.05). MA, on the other hand, increased the withdrawal threshold in animals with SNI and joint inflammation, but not chronic muscle pain. TENS and SCS produce similar effects in neuropathic, inflammatory and non-inflammatory muscle pain models while MA is only effective in inflammatory and neuropathic pain models.

Spinal Cord Stimulation

Pain

Transcutaneous Electric Nerve Stimulation

Knee Joint

Inflammation

Myalgia

Neuralgia

Acupuncture Therapy

Details

Title: Subtitle: Transcutaneous electrical nerve stimulation, acupuncture, and spinal cord stimulation on neuropathic, inflammatory and, non-inflammatory pain in rat models
Creators: Karina Laurenti Sato - Department of Physical Therapy, Federal University of Sergipe, Sao Cristovao, Brazil
Luciana Sayuri Sanada - Department of Physical Therapy, Physiotherapy Postgraduate Program, Santa Catarina State University, Florianopolis, Brazil
Morgana Duarte da Silva - Department of Physical Therapy, Federal University of Pampa, Uruguaiana, Brazil
Rodrigo Okubo - Department of Physical Therapy, Physiotherapy Postgraduate Program, Santa Catarina State University, Florianopolis, Brazil
Kathleen A Sluka - Department of Physical Therapy and Rehabilitation Science, Pain Research Program, University of Iowa, Iowa City, IA, USA
Resource Type: Journal article
Publication Details: The Korean journal of pain, Vol.33(2), pp.121-130
DOI: 10.3344/kjp.2020.33.2.121
PMID: 32235012
PMCID: PMC7136295
NLM abbreviation: Korean J Pain
ISSN: 2005-9159
eISSN: 2093-0569
Publisher: Korea (South)
Language: English
Date published: 04/01/2020
Academic Unit: Iowa Neuroscience Institute; Nursing; Physical Therapy and Rehabilitation Science; Neuroscience and Pharmacology
Record Identifier: 9984070268802771

Metrics

27 Record Views

13 Times Cited - Web of Science