Journal article
"Transfer" of power: The intersection of DNA virus infection and tRNA biology
Seminars in cell & developmental biology, Vol.146, pp.31-39
09/15/2023
DOI: 10.1016/j.semcdb.2023.01.011
PMCID: PMC10101907
PMID: 36682929
Abstract
Transfer RNAs (tRNAs) are at the heart of the molecular biology central dogma, functioning to decode messenger RNAs into proteins. As obligate intracellular parasites, viruses depend on the host translation machinery, including host tRNAs. Thus, the ability of a virus to fine-tune tRNA expression elicits the power to impact the outcome of infection. DNA viruses commonly upregulate the output of RNA polymerase III (Pol III)-dependent transcripts, including tRNAs. Decades after these initial discoveries we know very little about how mature tRNA pools change during viral infection, as tRNA sequencing methodology has only recently reached proficiency. Here, we review perturbation of tRNA biogenesis by DNA virus infection, including an emerging player called tRNA-derived fragments (tRFs). We discuss how tRNA dysregulation shifts the power landscape between the host and virus, highlighting the potential for tRNA-based antivirals as a future therapeutic.
Details
- Title: Subtitle
- "Transfer" of power: The intersection of DNA virus infection and tRNA biology
- Creators
- Sarah E Dremel - National Cancer InstituteAriana R Jimenez - University of IowaJessica M Tucker - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Seminars in cell & developmental biology, Vol.146, pp.31-39
- DOI
- 10.1016/j.semcdb.2023.01.011
- PMID
- 36682929
- PMCID
- PMC10101907
- NLM abbreviation
- Semin Cell Dev Biol
- ISSN
- 1084-9521
- eISSN
- 1096-3634
- Grant note
- DOI: 10.13039/100017540, name: NHLBI Division of Intramural Research, award: IRG-21-141-46, ZIA BC011176; DOI: 10.13039/100000002, name: National Institutes of Health; DOI: 10.13039/100000048, name: American Cancer Society; DOI: 10.13039/100008893, name: University of Iowa
- Language
- English
- Electronic publication date
- 01/20/2023
- Date published
- 09/15/2023
- Academic Unit
- Microbiology and Immunology
- Record Identifier
- 9984362758602771
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