Journal article
Transformational Changes Between Non-Small Cell and Small Cell Lung Cancer-Biological and Clinical Relevance-A Review
American journal of clinical oncology, Vol.43(9), pp.670-675
09/01/2020
DOI: 10.1097/COC.0000000000000720
PMID: 32889839
Abstract
During the course of therapy, patients with small cell lung cancer have been noted to develop transformation to non-small cell lung cancer and conversely, patients with non-small cell lung cancer have had transformation to small cell lung cancer or other non-small cell histologies. Transformation may occur after prior tyrosine kinase inhibitors, chemotherapy, immunotherapy or radiation therapy. These changes reflect on the overlapping biology of these cell types and the clinical need for re-biopsy at times of disease progression. The optimum therapy after transformation will depend upon prior therapies received, the functional capacity of the patient, and further research to define the best therapy options.
Details
- Title: Subtitle
- Transformational Changes Between Non-Small Cell and Small Cell Lung Cancer-Biological and Clinical Relevance-A Review
- Creators
- Gerald Clamon - University of Iowa Hospitals and ClinicsWilliam Zeitler - Univ Iowa Hosp & Clin, Dept Internal Med, Div Hematol Oncol Blood & Marrow Transplantat, 200 Hawkins Dr,C32 GH, Iowa City, IA 52242 USAJosiah An - University of IowaTaher A. Hejleh - Univ Iowa Hosp & Clin, Dept Internal Med, Div Hematol Oncol Blood & Marrow Transplantat, 200 Hawkins Dr,C32 GH, Iowa City, IA 52242 USA
- Resource Type
- Journal article
- Publication Details
- American journal of clinical oncology, Vol.43(9), pp.670-675
- Publisher
- Lippincott Williams & Wilkins
- DOI
- 10.1097/COC.0000000000000720
- PMID
- 32889839
- ISSN
- 0277-3732
- eISSN
- 1537-453X
- Number of pages
- 6
- Language
- English
- Date published
- 09/01/2020
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
- Record Identifier
- 9984359767902771
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