Transforming Growth Factor-beta Polymorphisms and Cardiac Allograft Rejection

Raymond L Benza; Christopher S Coffey; Dawn M Pekarek; Joseph P Barchue; Jose A Tallaj; Michael J Passineau; Hernan E Grenett

doi:10.1016/j.healun.2009.06.001

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Transforming Growth Factor-beta Polymorphisms and Cardiac Allograft Rejection

Journal article

Peer reviewed

Transforming Growth Factor-beta Polymorphisms and Cardiac Allograft Rejection

Raymond L Benza, Christopher S Coffey, Dawn M Pekarek, Joseph P Barchue, Jose A Tallaj, Michael J Passineau and Hernan E Grenett

The Journal of heart and lung transplantation, Vol.28(10), pp.1057-1062

2009

DOI: 10.1016/j.healun.2009.06.001

PMCID: PMC2796559

PMID: 19782287

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https://www.ncbi.nlm.nih.gov/pmc/articles/2796559View

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Abstract

Cytokine gene polymorphisms regulate cytokine expression. We analyzed transforming growth factor-beta (TGF-β) allelic variation in codon 25 in susceptibility to acute rejection episodes in cardiac transplant recipients. Between June 1997 and December 2001, 123 de novo heart transplants were performed at UAB with analysis based on 109 patients. Clinical and laboratory data were recorded at intervals up to 1 year post-transplant. Recipient genotypes for TGF-β (codon 25) were determined using polymerase chain reaction (PCR) sequence-specific primers. Correlations between TGF-β genotypes and acute rejection were made using Kaplan–Meier plots and parametric hazard models. Of the patients enrolled, 72% had at least one rejection and 46% had multiple rejections in the first year post-transplant. Among those ≥55 years of age at transplant, patients with the GG genotype had significantly fewer rejections as compared to those with the CC or GC genotype (1.25 vs 2.5, p < 0.01). There was no difference in risk of rejection between the genotype groups among patients <50 years of age at transplant ( p = 0.43). Similar results were observed when we used time to cumulative Grade 2R or greater rejection as the outcome. The GG TGF-β genotype may protect against acute rejection in older recipients during the first year after transplant.

Details

Title: Subtitle: Transforming Growth Factor-beta Polymorphisms and Cardiac Allograft Rejection
Creators: Raymond L Benza - Division of Cardiovascular Medicine, Allegheny General Hospital, Pittsburgh, Pennsylvania
Christopher S Coffey - School of Public Health, Department of Biostatistics, Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, Alabama
Dawn M Pekarek - School of Medicine, Department of Genetics, Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, Alabama
Joseph P Barchue - School of Medicine, Department of Medicine, Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, Alabama
Jose A Tallaj - School of Medicine, Department of Medicine, Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, Alabama
Michael J Passineau - Division of Cardiovascular Medicine, Allegheny General Hospital, Pittsburgh, Pennsylvania
Hernan E Grenett - School of Medicine, Department of Medicine, Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, Alabama
Resource Type: Journal article
Publication Details: The Journal of heart and lung transplantation, Vol.28(10), pp.1057-1062
DOI: 10.1016/j.healun.2009.06.001
PMID: 19782287
PMCID: PMC2796559
NLM abbreviation: J Heart Lung Transplant
ISSN: 1053-2498
eISSN: 1557-3117
Publisher: Elsevier Inc
Language: English
Date published: 2009
Academic Unit: Biostatistics
Record Identifier: 9984214798402771

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