Transfusion-associated Chagas disease (American trypanosomiasis) in Mexico : implications for transfusion medicine in the United States

Louis V Kirchhoff; Patricia Paredes; Abel LOMELI-GUERRERO; Mario PAREDES-ESPINOZA; Carlos S RON-GUERRERO; Manuel DELGADO-MEJIA; José G PENA-MUNOZ

doi:10.1111/j.1537-2995.2006.00715.x

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Transfusion-associated Chagas disease (American trypanosomiasis) in Mexico : implications for transfusion medicine in the United States

Journal article

Peer reviewed

Transfusion-associated Chagas disease (American trypanosomiasis) in Mexico : implications for transfusion medicine in the United States

Louis V Kirchhoff, Patricia Paredes, Abel LOMELI-GUERRERO, Mario PAREDES-ESPINOZA, Carlos S RON-GUERRERO, Manuel DELGADO-MEJIA and José G PENA-MUNOZ

Transfusion (Philadelphia, Pa.), Vol.46(2), pp.298-304

2006

DOI: 10.1111/j.1537-2995.2006.00715.x

PMID: 16441610

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Abstract

BACKGROUND: Trypanosoma cruzi, the protozoan cause of Chagas disease, causes life-long infection and is easily transmitted by blood transfusion. Our goals were to determine the prevalence of Chagas disease among donors in five Mexican blood banks, to look for evidence of transmission of T. cruzi by transfusion, and to evaluate two serologic assays for Chagas disease. STUDY DESIGN and METHODS: Blood samples from donors were tested initially with the Abbott Chagas EIA or the Meridian Chagas' IgG ELISA. Samples giving readings that were at least 50% of the cutoffs were run in a confirmatory radioimmune precipitation assay (RIPA), as were samples from recipients of blood products from RIPA-positive donors. RESULTS: The overall prevalence of Chagas disease was 1/133 (55/7,296; 0.75%). In addition, 4 of 9 surviving recipients of blood products from T. cruzi-infected donors were in turn infected. Using the manufacturers' recommended cutoffs, the sensitivity and specificity of the Abbott test were 92.0% (23/25) and 99.8% (2,865/2,872) respectively, and the corresponding values for the Meridian assay were 70.0% (21/30) and 100.0% (4,369/4,369). CONCLUSIONS: These findings indicate clearly that transfusion-associated transmission of T. cruzi is occurring in the study areas. Serologic testing of blood donors for Chagas disease should be performed there and in the rest of Mexico. The two screening assays evaluated may lack the accuracy necessary for blood donor testing when used as suggested by the manufacturers.

Respiratory System

Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy

Biological and medical sciences

Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis

Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care

Intensive care medicine

Investigative techniques, diagnostic techniques (general aspects)

Medical sciences

Radiodiagnosis. Nmr imagery. Nmr spectrometry

Transfusions. Complications. Transfusion reactions. Cell and gene therapy

Details

Title: Subtitle: Transfusion-associated Chagas disease (American trypanosomiasis) in Mexico : implications for transfusion medicine in the United States
Creators: Louis V Kirchhoff - University of Iowa
Patricia Paredes - Departments of Internal Medicine and Epidemiology, University of Iowa, United States
Abel LOMELI-GUERRERO - Departments of Internal Medicine and Epidemiology, University of Iowa, United States
Mario PAREDES-ESPINOZA - Departments of Internal Medicine and Epidemiology, University of Iowa, United States
Carlos S RON-GUERRERO - Departments of Internal Medicine and Epidemiology, University of Iowa, United States
Manuel DELGADO-MEJIA - Departments of Internal Medicine and Epidemiology, University of Iowa, United States
José G PENA-MUNOZ - Departments of Internal Medicine and Epidemiology, University of Iowa, United States
Resource Type: Journal article
Publication Details: Transfusion (Philadelphia, Pa.), Vol.46(2), pp.298-304
Publisher: Blackwell Publishing
DOI: 10.1111/j.1537-2995.2006.00715.x
PMID: 16441610
ISSN: 0041-1132
eISSN: 1537-2995
Language: English
Date published: 2006
Academic Unit: Psychiatry; Infectious Diseases; Epidemiology; Internal Medicine
Record Identifier: 9984280874202771

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