Journal article
Transfusion has no effect on recurrence in hepatitis C after liver transplantation
Acta anaesthesiologica Scandinavica, Vol.54(10), pp.1224-1232
11/01/2010
DOI: 10.1111/j.1399-6576.2010.02313.x
PMID: 21069900
Abstract
Background
The literature suggests that blood product transfusions have a negative impact on the survival of liver transplant patients. We investigated the impact of intraoperative blood product usage on the survival of liver transplantation patients being transplanted for hepatitis C-related end-stage liver disease. In addition, we analyzed a potentially more sensitive metric, namely disease recurrence and fibrosis progression, obtained from follow-up liver biopsies.
Methods
We retrospectively studied 194 consecutive patients with hepatitis C virus (HCV) undergoing liver transplantation. To investigate the effect of red blood cell (RBC) or platelet transfusions on post-transplant HCV recurrence, hepatic biopsy data from 4 months and 1 year after transplantation were studied. In addition, survival data were analyzed.
Results
There was no effect of intraoperative RBC or platelet transfusion on either 1- or 5-year patient survival following liver transplantation. There was no difference in HCV disease recurrence or progression of hepatic fibrosis at 4 months or 1 year attributable either to RBC or to platelet transfusion.
Conclusion
This study was not able to confirm an effect on the survival of HCV-infected liver transplant patients related to intraoperative transfusion of RBCs or platelets. In addition, these transfusions had no effect on HCV recurrence or fibrosis progression. This is not to condone a liberal transfusion practice, but rather to reassure that when clinically indicated, transfusion does not have a significant impact on patient survival or disease recurrence in HCV-infected liver transplant patients.
Details
- Title: Subtitle
- Transfusion has no effect on recurrence in hepatitis C after liver transplantation
- Creators
- M. J. Rice - University of FloridaA. Wendling - University of FloridaR. J. Firpi - Florida CollegeA. W. Hemming - University of FloridaD. R. Nelson - Florida CollegeW. K. Schwab - University of FloridaN. Gravenstein - University of FloridaT. E. Morey - University of Florida
- Resource Type
- Journal article
- Publication Details
- Acta anaesthesiologica Scandinavica, Vol.54(10), pp.1224-1232
- Publisher
- Wiley
- DOI
- 10.1111/j.1399-6576.2010.02313.x
- PMID
- 21069900
- ISSN
- 0001-5172
- eISSN
- 1399-6576
- Number of pages
- 9
- Language
- English
- Date published
- 11/01/2010
- Academic Unit
- Surgery
- Record Identifier
- 9984322811702771
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