Transgenic approaches to cognition

Mark Mayford; Ted Abel; Eric R Kandel

doi:10.1016/0959-4388(95)80019-0

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Journal article

Peer reviewed

Transgenic approaches to cognition

Mark Mayford, Ted Abel and Eric R Kandel

Current opinion in neurobiology, Vol.5(2), pp.141-148

1995

DOI: 10.1016/0959-4388(95)80019-0

PMID: 7620300

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Abstract

Reverse genetic techniques, including gene ‘knockouts’ and transgenesis, allow defined mutations to be introduced into the mouse genome. The application of these techniques to neurobiology is beginning to provide a bridge between genes and cognition. Specifically, genetically altered mice make it possible to explore molecular mechanisms underlying implicit and explicit forms of learning, short-term and long-term memory, and emotional behaviors. The analysis of these mutant mice has begun to link specific behavioral deficits to defined changes in synaptic physiology.

KA-1—ionotropic glutamate (kainate) receptor

PKC—protein kinase C

CaMKII—Ca 2+/calmodulin-dependent protein kinase II

PKA—protein kinase A

NO—nitric oxide

CREB—cAMP-responsive element binding protein

5-HT—5-hydroxytryptamine (serotonin)

NMDA— N-methyl- d-aspartate

nNOS—neuronal NOS

LTP—long-term potentiation

NOS—NO synthase

Details

Title: Subtitle: Transgenic approaches to cognition
Creators: Mark Mayford
Ted Abel
Eric R Kandel
Resource Type: Journal article
Publication Details: Current opinion in neurobiology, Vol.5(2), pp.141-148
Publisher: Elsevier Ltd
DOI: 10.1016/0959-4388(95)80019-0
PMID: 7620300
ISSN: 0959-4388
eISSN: 1873-6882
Language: English
Date published: 1995
Academic Unit: Molecular Physiology and Biophysics; Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neuroscience and Pharmacology; Biochemistry and Molecular Biology
Record Identifier: 9984065830402771

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