Journal article
Transient Intrapulmonary Shunting in a Patient Treated With b2-Adrenergic Agonists for Status Asthmaticus
Pediatrics (Evanston), Vol.133(4), pp.E1087-E1091
04/01/2014
DOI: 10.1542/peds.2013-1171
PMCID: PMC3966497
PMID: 24639274
Abstract
Intrapulmonary arteriovenous anastomoses (IPAVs) are large-diameter pathways that directly connect the arterial and venous networks, bypassing the pulmonary capillaries. Ubiquitously present in healthy humans, these pathways are recruited in experimental conditions by exercise, hypoxia, and catecholamines and have been previously shown to be closed by hyperoxia. Whether they play a role in pulmonary pathophysiology is unknown. Here, we describe IPAV recruitment associated with hypoxemia and right-to-left shunt in a patient with status asthmaticus, treated with agonists of the B-2-adrenergic pathway. Our observation of IPAVs in a pediatric patient, mechanically ventilated with 100% O-2, suggests that these pathways are recruited in clinically important circumstances and challenges the notion that IPAVs are always closed by alveolar hyperoxia.
Details
- Title: Subtitle
- Transient Intrapulmonary Shunting in a Patient Treated With b2-Adrenergic Agonists for Status Asthmaticus
- Creators
- Melissa L. Bates - Critical Care Division, Department of Pediatrics and the John Rankin Laboratory of Pulmonary Medicine, and.Joseph E. Jacobson - Michigan State UniversityMarlowe W. Eldridge - University of Wisconsin–Madison
- Resource Type
- Journal article
- Publication Details
- Pediatrics (Evanston), Vol.133(4), pp.E1087-E1091
- DOI
- 10.1542/peds.2013-1171
- PMID
- 24639274
- PMCID
- PMC3966497
- NLM abbreviation
- Pediatrics
- ISSN
- 0031-4005
- eISSN
- 1098-4275
- Publisher
- American Academy of Pediatrics
- Number of pages
- 5
- Grant note
- National Institutes of Health (NIH); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA 5R01HL086897; 5T32HL007654 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA American Heart Association T32HL007654 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI)
- Language
- English
- Date published
- 04/01/2014
- Academic Unit
- Stead Family Department of Pediatrics; Fraternal Order of Eagles Diabetes Research Center; Health, Sport, and Human Physiology ; Internal Medicine
- Record Identifier
- 9984259399702771
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